39169-63-6Relevant academic research and scientific papers
β-Hydroxyalkylation of sterically hindered phenols with epoxides in acid medium
Krysin,Amitina,Egorova,Vasiliev
experimental part, p. 354 - 360 (2011/06/27)
Reactions of 2,6-dialkylphenols with ethylene oxide, propylene oxide and epichlorohydrin in the presence of SnCl4 at the temperature from -5 to +5°C leads to the formation of respective phenols containing a hydroxy group in the β-position of the aliphatic chain of the para-substituent. The conditions for maximum selectivity of the reaction of 2,6-di-tert-butylphenol with ethylene oxide were determined. By HPLC-MS method the directions of the side reactions were explored. The method has been successfully tested in a pilot installation. With 2,6-dimethylphenol instead of 2,6-di-tert-butylphenol a sharp increase occurs in the content of ethers in the reaction product. With epichlorohydrin, 2,6-di-tert-butylphenol affords a product, which is easily converted into an epoxide containing a sterically hindered phenol in its structure.
Development of a one-stage synthesis of 2,6-di-tert-4-ethylbutylphenol from 2,6-di-tert-butylphenol
Krysin,Pokrovskii
experimental part, p. 1728 - 1733 (2009/02/06)
Investigation of the catalyzed reaction of 2,6-di-tert-butylphenol with ethanol, ethylene glycol, oligomeric glycols, and paraldehyde in a strongly basic medium permitted to develop a technologically suitable procedure for manufacture of 2,6-di-tert-4-ethyl-butylphenol, used in the synthesis of Antioxidant-425.
