39172-91-3Relevant academic research and scientific papers
Gold(I)-catalyzed benzannulation of 3-hydroxy-1,5-enynes: an efficient synthesis of substituted tetrahydronaphthalenes and related compounds
Grisé, Christiane M.,Rodrigue, Eric M.,Barriault, Louis
, p. 797 - 808 (2008)
We report a novel gold(I)-catalyzed benzannulation of 3-hydroxy-1,5-enynes to prepare tetrahydronaphthalenes. The reaction is catalyzed by 2.5 mol % Ph3PAuCl and 2.5 mol % AgOTf in dichloromethane. We discovered that this process can be also catalyzed by 1 mol % Ph3PAuCl and 1 mol % TfOH. To the best of our knowledge, this constitutes the first report of an active gold catalyst generated from Au(PPh3)Cl and triflic acid. This mild process is compatible with a variety of functional groups and proves to be an effective method to synthesize various meta-substituted aromatic rings in good yields.
Gold-catalyzed synthesis of substituted tetrahydronaphthalenes
Grise, Christiane M.,Barriault, Louis
, p. 5905 - 5908 (2007/10/03)
(Diagram presented) We report a gold-catalyzed benzannulation of 3-hydroxy-1,5-enynes to generate tetrahydronaphthalenes. This mild process proves to be an effective method to synthesize various metasubstituted aromatic rings in good yields.
