39180-81-9

Usage

Uses

Used in Pharmaceutical Research:
[(2,4-dichlorophenyl)methyl](propyl)amine is used as a research chemical for studying the effects and mechanisms of action of stimulant drugs on the central nervous system. Its role as an NDRA makes it a valuable compound for understanding the interactions between norepinephrine and dopamine in the brain.
Used in Attention Deficit Hyperactivity Disorder (ADHD) Treatment Research:
In the medical field, [(2,4-dichlorophenyl)methyl](propyl)amine is used as a potential therapeutic agent for the treatment of ADHD. Its stimulant effects and ability to modulate neurotransmitter levels make it a candidate for further research into its efficacy and safety in managing ADHD symptoms.
Used in Obesity Treatment Research:
Additionally, dichlorophenylpropylamine has been studied for its potential applications in the treatment of obesity. Its effects on the central nervous system and its ability to influence neurotransmitter levels may contribute to the development of new therapies for weight management and obesity treatment.
Used in Controlled Substances Regulation:
Due to its potential for abuse and addiction, [(2,4-dichlorophenyl)methyl](propyl)amine is a controlled substance in many countries. It is used as a reference point for regulatory agencies to develop and enforce policies aimed at preventing the misuse and diversion of stimulant drugs.

InChI:InChI=1/C10H13Cl2N/c1-2-5-13-7-8-3-4-9(11)6-10(8)12/h3-4,6,13H,2,5,7H2,1H3

Upstream product

• 107-10-8 propylamine 
• 94-99-5 2,4-Dichlorobenzyl chloride 
• 874-42-0 2,4-dichlorobenzaldeyhde 
• 75692-60-3 2,4-dichlorobenzyliminepropane 

Downstream Products

• 100120-24-9 dichloro-acetic acid-[(2,4-dichloro-benzyl)-propyl-amide] 
• 55245-78-8 C₁₁H₁₂Cl₃NO 

Relevant academic research and scientific papers

Tertiary Amine Pyrazolones and Their Salts as Inhibitors of Mutant Superoxide Dismutase 1-Dependent Protein Aggregation for the Treatment of Amyotrophic Lateral Sclerosis

Pyrazolone derivatives have previously been found to be inhibitors of Cu/Zn superoxide dismutase 1 (SOD1)-dependent protein aggregation, which extended survival of an amyotrophic lateral sclerosis (ALS) mouse model. On the basis of ADME analysis, we describe herein a new series of tertiary amine-containing pyrazolones and their structure-activity relationships. Further conversion to the conjugate salts greatly improved their solubility. Phosphate compound 17 exhibited numerous benefits both to cellular activity and to CNS-related drug-like properties in vitro and in vivo, including microsomal stability, tolerated toxicity, and blood-brain barrier permeation. These results indicate that tertiary amine pyrazolones comprise a valuable class of ALS drug candidates.

Benzylamines: Synthesis and evaluation of antimycobacterial properties

The synthesis of benzylamines with various N-alkyl chains and substituents in the aromatic system as well as their evaluation on Mycobacterium tuberculosis H 37 Ra are described. The most active compounds in this test, N-methyl-3-chlorobenzylamine (MIC 10.2 μg/mL), N-methyl-3,5-dichlorobenzylamine (93, MIC 10.2 μg/mL), and N-butyl-3,5-difluorobenzylamine (MIC 6.4 μg/mL), also exhibited a marked inhibitory effect on Mycobacterium marinum and Mycobacterium lufu used for the determination of antileprotic properties. The combination of 93 with aminosalicylic acid, streptomycin, or dapsone exert marked supra-additive effects on M. tuberculosis H 37 Ra.