39184-04-8Relevant academic research and scientific papers
Dopamine/serotonin receptor ligands. 131: Homologization of a benzindoloazecine-type dopamine receptor antagonist modulates the affinities for dopamine D1-D5 receptors
Enzensperger, Christoph,Lehmann, Jochen
, p. 6408 - 6411 (2006)
Enlarging the 10-membered ring of 7-methyl-6,7,8,9,14,15-hexahydro-5H- indolo[3,2-f][3]benzazecine (1, LE 300) yielded two homologue antagonists. Their affinities and inhibitory activities at D1-D5 receptors were measured by radiolig
Annulation reaction of cyclic pyridinium ylides with: In situ generated azoalkenes for the construction of spirocyclic skeletons
Quan, Bao-Xue,Yuan, Wei-Cheng,Zhang, Ming-Liang,Zhang, Xiao-Mei,Zhao, Jian-Qiang,Zhou, Ming-Qiang,Zhuo, Jun-Rui
supporting information, p. 1886 - 1891 (2020/03/23)
Two new types of cyclic pyridinium ylides were designed and further used in reactions with azoalkenes to access structurally diverse spirocyclic compounds. A range of spiropyrazoline oxindoles could be smoothly obtained in up to 99% yield via a [4 + 1] annulation process with oxindole 3-pyridinium ylides as C1 synthons. Similarly, a series of spiropyrazoline indanones could be prepared with indanone 2-pyridinium ylides as C1 synthons. This work represents the first example of cyclic pyridinium ylides as C1 synthons for the efficient construction of spirocyclic compounds.
