391859-17-9Relevant academic research and scientific papers
Asymmetric total synthesis of fredericamycin a: An intramolecular cycloaddition pathway
Akai, Shuji,Tsujino, Toshiaki,Fukuda, Nobuhisa,Iio, Kiyosei,Takeda, Yoshifumi,Kawaguchi, Ken-Ichi,Naka, Tadaatsu,Higuchi, Kazuhiro,Akiyama, Emi,Fujioka, Hiromichi,Kita, Yasuyuki
, p. 6286 - 6297 (2007/10/03)
The asymmetric total synthesis of the potent antitumor antibiotic fredericamycin A ((S)-1) was achieved by the intramolecular [4+2] cycloaddition of the silylene-protected styrene derivative (S)-7 followed by the aromatic Pummerer-type reaction of the sul
Enantiodivergent synthesis of either enantiomer of ABCDE-ring analogue of antitumor antibiotic fredericamycin A via intramolecular [4 + 2] cycloaddition approach
Akai, Shuji,Tsujino, Toshiaki,Fukuda, Nobuhisa,Iio, Kiyosei,Takeda, Yoshifumi,Kawaguchi, Ken-Ichi,Naka, Tadaatsu,Higuchi, Kazuhiro,Kita, Yasuyuki
, p. 4015 - 4018 (2007/10/03)
matrix presented An intramolecular enantiodivergent synthesis of both enantiomers of the ABCDE-ring analogue 22 of fredericamycin A is reported. Key steps involved an intramolecular [4 + 2] cycloaddition of 17 and an aromatic Pummerer-type reaction of 19.
