39186-15-7

Upstream product

• 622-59-3 1-isothiocyanato-4-methylbenzene 
• 103988-10-9 3-p-tolylthiocarbamoyl-carbazic acid ethyl ester 
• 106-49-0 p-toluidine 
• 134832-80-7 benzyl β-(N-p-tolylthiocarbamyl)thiocarbazinate 

Downstream Products

• 110062-48-1 4-p-tolyl-3-methylthio-Δ²-1,2,4-triazolin-5-one 
• 115213-65-5 2-methyl-5-methylsulfanyl-4-p-tolyl-2,4-dihydro-[1,2,4]triazol-3-one 
• 134832-77-2 3-benzylmercapto-4(p-tolyl)-1,2,4-triazolin-5-one 

Relevant academic research and scientific papers

Domino synthesis of novel series of 4-substituted 5-thioxo-1,2,4- triazolidin-3-one derivatives

The efficient synthesis of 4-substituted 5-thioxo-1,2,4-triazolidin-3-one derivatives (4-substituted thiourazoles) via domino combination of thiophosgene, aliphatic or aromatic amines, and ethyl carbazate is presented.

Thiocarbazinic acids: Interaction of carbonoxysulphide with thiosemicarbazides - Synthesis of &β-(thiocarbamyl)thiocarbazinates and 1,3,4-oxadiazole and 1,2,4-triazole derivatives

Interaction of carbon oxysulphide with 4-alkyl/arylthiosemicarbazides (I) in ethanol in the presence of sodium hydroxide forms sodium β-(N-alkyl/arylthiocarbamyl)thiocarbazinates (II).Benzylation of the latter (II) affords 5-alkyl/arylamino-2-benzylmercapto-1,3,4-oxadiazoles (IV), which can also be obtained by a one-pot synthesis involving the reaction of I with carbon oxysulphide in DMF in the presence of triethylamine and benzyl chloride.The syntheses of benzyl β-(N-alkyl/arylthiocarbamyl)thiocarbazinates (III) and 4-aryl-3-mercapto-1,2,4-triazolin-5-ones (VII) are also reported.Some of the compounds exhibit antibacterial activity.