39187-97-8

Usage

Uses

Used in Pharmaceutical Industry:
2-(4-fluorophenyl)thiazole is used as a building block for the synthesis of biologically active molecules, contributing to the development of new pharmaceutical compounds. Its unique structure allows for the creation of drugs with specific therapeutic properties, enhancing the range of treatments available for various medical conditions.
Used in Agrochemical Industry:
In the agrochemical sector, 2-(4-fluorophenyl)thiazole is utilized as a component in the synthesis of agrochemicals. Its incorporation into these products can lead to the development of more effective and targeted pesticides, herbicides, and other agricultural chemicals, improving crop protection and yield.
Used in Material Science:
2-(4-fluorophenyl)thiazole is employed as a valuable component in the development of new materials with specific properties. Its unique chemical structure allows for the creation of materials with tailored characteristics, such as improved stability, reactivity, or selectivity, which can be applied in various industries, including electronics, coatings, and advanced materials.

InChI:InChI=1/C10H9NS/c1-8-4-2-3-5-9(8)10-11-6-7-12-10/h2-7H,1H3

Upstream product

• 3034-53-5 2-bromo-1,3-thiazole 
• 16419-60-6 2-Methylphenylboronic acid 
• 288-47-1 1,3-thiazole 
• 615-37-2 ortho-methylphenyl iodide 
• 1826-11-5 2-phenylthiazole 
• 823-96-1 Trimethylboroxine 

Downstream Products

• 1078735-71-3 C₁₇H₁₅NOS 
• 1078735-75-7 C₂₀H₁₅NS 
• 1021602-72-1 C₂₀H₁₆N₂S₂ 
• 1236376-58-1 2-(2,6-dimethylphenyl)thiazole 
• 1217887-61-0 C₁₁H₈F₃NS 

Relevant academic research and scientific papers

Aromatic C-H Methylation and Other Functionalizations via the Rh(III)-Catalyzed Migratory Insertion of Bis(phenylsulfonyl)carbene and Subsequent Transformations

The Rh(III)-catalyzed migratory insertion of bis(phenylsulfonyl)carbene into aromatic C-H bonds has been developed. A variety of bis(phenylsulfonyl)methyl derivatives were prepared with good yields under mild conditions. The methylated products were readily obtained after reductive desulfonylation. Furthermore, the diverse transformations of bis(phenylsulfonyl)methyl to trideuteriomethyl, aldehyde, and other functional groups were demonstrated.

Cobalt-catalysed C–H methylation for late-stage drug diversification

The magic methyl effect is well acknowledged in medicinal chemistry, but despite its significance, accessing such analogues via derivatization at a late stage remains a pivotal challenge. In an effort to mitigate this major limitation, we here present a strategy for the cobalt-catalysed late-stage C–H methylation of structurally complex drug molecules. Enabling broad applicability, the transformation relies on a boron-based methyl source and takes advantage of inherently present functional groups to guide the C–H activation. The relative reactivity observed for distinct classes of functionalities were determined and the sensitivity of the transformation towards a panel of common functional motifs was tested under various reaction conditions. Without the need for prefunctionalization or postdeprotection, a diverse array of marketed drug molecules and natural products could be methylated in a predictable manner. Subsequent physicochemical and biological testing confirmed the magnitude with which this seemingly minor structural change can affect important drug properties. [Figure not available: see fulltext.]

Rhodium(III)-Catalyzed ortho -C-H Alkylation of 2-Arylbenzothiazoles and 2-Arylthiazoles with Potassium Alkyltrifluoroborates

A general and efficient Rh(III)-catalyzed ortho-C-H alkylation of 2-arylbenzothizazoles and 2-arylthiazoles with potassium alkyltrifluoroborates has been developed. The present method leads to the construction of a library of alkylated 2-arylbenzothiazole

Programmed synthesis of arylthiazoles through sequential C-H couplings

A programmed synthesis of privileged arylthiazoles via sequential C-H couplings catalyzed by palladium or nickel catalysts has been accomplished. This versatile protocol can supply all possible arylthiazole substitution patterns (2-aryl, 4-aryl, 5-aryl, 2

Efficient coupling of heteroaryl halides with arylboronic acids in the presence of a palladium-tetraphosphine catalyst

Cis, cis, cis-1,2,3,4-tetrakis(diphenylphosphinomethyl) cyclopentane: ·1/2[PdCl(C3H5)]2 system catalyses the Suzuki cross-coupling of heteroaryl halides with a range of arylboronic acids with very high ratio substrate/catalyst in good yields. Substrates such as pyridines, quinolines, thiophenes, an indole, pyrimidines or a furane have been used successfully.