391957-11-2

Upstream product

• 874-97-5 3-(hydroxymethyl)benzonitrile 
• 24964-64-5 3-Cyanobenzaldehyde 
• 586373-51-5 3-(tert-butyl-dimethyl-silanyloxymethyl)-benzonitrile 

Downstream Products

• 226070-69-5 1,1-dimethylethyl {[3-(hydroxymethyl)phenyl]methyl}carbamate 
• 586373-50-4 {3-[3-bromo-4-(4-fluorobenzyloxy)-2-oxo-2H-pyridin-1-ylmethyl]benzyl}carbamic acid tert-butyl ester 
• 220364-34-1 tert-butyl (3-(bromomethyl)benzyl)carbamate 

Relevant academic research and scientific papers

SUBSTITUTED PYRIDINONES

Disclosed are compounds of Formula (I) and pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4, and R5 are defined herein. These compounds are useful for treating diseases and conditions caused or exacerbated by unregulated p38 MAP Kinase and/or TNF activity. Pharmaceutical compositions containing the compounds, methods of preparing the compounds and methods of treatment using the compounds are also disclosed.

Serotonin reuptake inhibitor

A serotonin reuptake inhibitor containing a cyclic amine represented by the following formula, a prodrug thereof, or a pharmaceutically acceptable salt of said cyclic amine or prodrug as an active ingredient: wherein R0 is a hydrogen atom, a halogen atom, an alkyl group, a substituted alkyl group, a hydroxyl group, an alkoxy group or the like, R3 is a hydrogen atom or the like, Y is an alkylene group or the like, Z is a hydrogen atom, a cycloalkyl group, an aryl group or the like, n is 1, 2 or 3, and m is 2, 3, 4, 5 or 6.