39202-36-3

Basic information

• Product Name: BIS(8-AMINOOCTYL)AMINE
• Synonyms: BIS(8-AMINOOCTYL)AMINE;8,8μ-Iminodioctylamine
• CAS NO: 39202-36-3
• Molecular Formula: C₁₆H₃₇N₃
• Molecular Weight: 271.48508
• Mol File: 39202-36-3.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 379.56 °C at 760 mmHg
• Flash Point: 216.193 °C
• Appearance: /
• Density: 0.879 g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.474
• CAS DataBase Reference: BIS(8-AMINOOCTYL)AMINE(CAS DataBase Reference)
• NIST Chemistry Reference: BIS(8-AMINOOCTYL)AMINE(39202-36-3)
• EPA Substance Registry System: BIS(8-AMINOOCTYL)AMINE(39202-36-3)

Safety Data

• Hazard Codes: C
• Statements: 34
• Safety Statements: 26-36/37/39-45
• RIDADR: 3259
• HazardClass: 8
• PackingGroup: III
• Hazardous Substances Data: 39202-36-3(Hazardous Substances Data)

Usage

Uses

N-(8-Aminooctyl)-1,8-octanediamine is an intermediate used in the preparation of alkylguanidine oligomer with potent antibacterial activity against gram-positive bacteria and gram-negative bacteria.

InChI:InChI=1/C16H37N3/c17-13-9-5-1-3-7-11-15-19-16-12-8-4-2-6-10-14-18/h19H,1-18H2

Upstream product

• 133497-22-0 1-Azido-8-bromooctane 
• 4549-32-0 1,8-dibromooctane 
• 373-44-4 1,8-diaminooctan 

Downstream Products

• 1176818-05-5 tert‐butyl N‐benzyl‐N‐({[8‐({8‐[({[(tert‐butoxy)carbonyl]amino}({[(tert‐butoxy)carbonyl]imino})methyl)amino]octyl}amino)octyl]amino}({[(tert‐butoxy)carbonyl]imino})methyl)carbamate 
• 1176817-96-1 1-amino-17-(N₁,N₂-bis(tert-butoxycarbonyl)-N₁-(benzyl)guanidine)-9-azaheptadecane 
• 13516-27-3 Caswell No_. 471D 

Relevant articles and documents

Alkyl-guanidine Compounds as Potent Broad-Spectrum Antibacterial Agents: Chemical Library Extension and Biological Characterization

Nowadays, the increasing of multidrug-resistant pathogenic bacteria represents a serious threat to public health, and the lack of new antibiotics is becoming a global emergency. Therefore, research in antibacterial fields is urgently needed to expand the currently available arsenal of drugs. We have recently reported an alkyl-guanidine derivative (2), characterized by a symmetrical dimeric structure, as a good candidate for further developments, with a high antibacterial activity against both Gram-positive and Gram-negative strains. In this study, starting from its chemical scaffold, we synthesized a small library of analogues. Moreover, biological and in vitro pharmacokinetic characterizations were conducted on some selected derivatives, revealing notable properties: broad-spectrum profile, activity against resistant clinical isolates, and appreciable aqueous solubility. Interestingly, 2 seems neither to select for resistant strains nor to macroscopically alter the membranes, but further studies are required to determine the mode of action.

Mixtures having antimicrobial or pesticidal effect

The present invention relates to mixtures of guanidated aliphatic polyamines, or their acid addition salts, having antimicrobial or pesticidal effect. More particularly the invention relates to such mixtures which have a total degree of guanidation exceeding 30%. The mixtures are suitable for agricultural and industrial use.