39208-00-9Relevant articles and documents
Modification of a promiscuous inhibitor shifts the inhibition from γ-secretase to FLT-3
Amombo, Ghislaine Marlyse Okala,Kramer, Thomas,Lo Monte, Fabio,Goering, Stefan,Fach, Matthias,Smith, Steven,Kolb, Stephanie,Schubenel, Robert,Baumann, Karlheinz,Schmidt, Boris
, p. 7634 - 7640 (2013/02/21)
The inhibition of FLT-3 activity is an interesting target for the treatment of acute myeloid leukemia (AML). The serendipitous identification of FLT-3 inhibitors from a CK1/γ-secretase programme provided compounds with dual inhibitory activity. We analyzed the structure-activity relationship of these inhibitors and derivatized them to arrive at compounds with reduced impact on γ-secretase activity and enhanced FLT-3 inhibition.
Highly selective and sensitive colorimetric probes for hypochlorite anion based on azo derivatives
Zhang, Dengqing
scheme or table, p. 397 - 401 (2010/11/05)
Two oxime-based colorimetric probes for the hypochlorite anion (ClO -) have been rationally designed and synthesized on basis of the mechanism of intramolecular charge transfer (ICT). Upon addition of ClO -, the probes displayed arou
Preparation, structures, and properties of new monocarbenium ion compounds stabilized by a 3-Guaiazulenyl group and an azobenzene unit: Comparative studies on three delocalized π-electron system
Takekuma, Shin-Ichi,Fukuda, Kenji,Kawase, Yasuko,Minematsu, Toshie,Takekuma, Hideko
experimental part, p. 879 - 890 (2009/12/25)
Reaction of guaiazulene (=7-isopropyl-1,4-dimethylazulene) with 4-hydroxyazobenzene-4-carbaldehyde in methanol in the presence of hexafluorophosphoric acid at 25°C for 2 h gives as high as 94% yield of a new monocarbenium ion compound (3-guaiazulenyl)[4-(
