39222-71-4

Upstream product

• 126-81-8 dimedone 
• 95-83-0 4-Chloro-1,2-phenylenediamine 
• 84691-47-4 3-(4-Chloro-2-nitro-phenylamino)-5,5-dimethyl-cyclohex-2-enone 

Downstream Products

• 1023540-34-2 C₂₁H₁₉Cl₂FN₂O 

Relevant academic research and scientific papers

Efficient Synthesis and Spectral Determination of 11-[(o-; m-; and p-substituted)-phenyl]-8-chloro-3,3-dimethyl-2,3,4,5,10, 11-hexahydro-1H-dibenzo[b,e][1,4]diazepin-1-ones

A new synthesis to obtain eleven novel derivatives of 11-[(o-; m-; and p-substituted)-phenyl]-8-chloro-3,3-dimethyl-2,3,4,5,10, 11-hexahydro-1H-dibenzo[b,e][1,4]diazepin-1-ones with possible pharmacological activity in the central nervous system in two efficient steps has been developed. The final products were obtained by condensation and cyclization between 3-[4-chloro-1,2-phenylenediamine]-5,5-dimethyl-2-cyclohexenone with (o-; m-; and p-substituted)benzaldehyde. The structure of all products was corroborated by ir, 1H-nmr, 13C-nmr and high resolution in ms.

Discovery and optimization of a novel Neuromedin B receptor antagonist

The discovery and parallel synthesis of potent, small molecule antagonists of Neuromedin B receptor based on the ary-hexahydro-dibenzodiazepin-1-one core is described.