392324-16-2Relevant academic research and scientific papers
Sulfonyl-phenyl-ureido benzamidines: A novel structural class of potent antimalarial agents
Leban, Johann,Pegoraro, Stefano,Dormeyer, Matthias,Lanzer, Michael,Aschenbrenner, Andrea,Kramer, Bernd
, p. 1979 - 1982 (2007/10/03)
The high throughput in silico screening of a virtual library into the structure of the P. falciparum lactate dehydrogenase (LDH) with the 4SCan technology yielded a series of biphenyl urea compounds. These were chemically optimized to a new structural class of potent antimalarial agents. The compounds did not inhibit plasmodium LDH enough to fully explain their potency. Therefore we conclude that an unknown mode of action may be the cause of the antimalarial activity.
Carbonic anhydrase inhibitors. Part 61. Quantum chemical QSAR of a group of benzenedisulfonamides
Clare, Brian W.,Supuran, Claudiu T.
, p. 463 - 474 (2007/10/03)
The synthesis of a large group of benzenesulfonamides containing both a primary and secondary sulfonamide moiety is described. These compounds are powerful inhibitors of several isozymes of the enzyme carbonic anhydrase. Separate QSAR's are given for inhi
