39234-83-8

Usage

Uses

Used in Pharmaceutical Industry:
4-NITRO-3-(TRIFLUOROMETHYL)BENZENESULFONYL CHLORIDE is used as a reagent for the synthesis of various pharmaceutical compounds. Its unique chemical structure allows it to be a valuable building block in the creation of new and effective medications.
Used in Agrochemical Synthesis:
In the agrochemical industry, 4-NITRO-3-(TRIFLUOROMETHYL)BENZENESULFONYL CHLORIDE is used as a building block in the synthesis of agrochemicals. Its properties contribute to the development of effective products for agricultural applications.
Used in Dye Synthesis:
4-NITRO-3-(TRIFLUOROMETHYL)BENZENESULFONYL CHLORIDE is utilized in the synthesis of dyes due to its chemical composition, which allows for the creation of a wide range of colorants for various applications.
Used in Specialty Chemicals:
4-NITRO-3-(TRIFLUOROMETHYL)BENZENESULFONYL CHLORIDE is also used in the synthesis of specialty chemicals, where its unique structure and properties are leveraged to produce high-quality products for specific industries.
Used in Drug Metabolism Research:
4-NITRO-3-(TRIFLUOROMETHYL)BENZENESULFONYL CHLORIDE is a potent and selective inhibitor of cytochrome P450 2C19, making it useful for studying drug metabolism and drug-drug interactions. This application aids in understanding how different drugs are processed within the body and how they may interact with one another.
Safety Precautions:
It is important to handle 4-NITRO-3-(TRIFLUOROMETHYL)BENZENESULFONYL CHLORIDE with care due to its corrosive nature, which can cause irritation to the skin, eyes, and respiratory system. Proper safety measures should be taken to minimize exposure and ensure the well-being of those working with 4-NITRO-3-(TRIFLUOROMETHYL)BENZENESULFONYL CHLORIDE.

InChI:InChI=1/C7H3ClF3NO4S/c8-17(15,16)4-1-2-6(12(13)14)5(3-4)7(9,10)11/h1-3H

Upstream product

• 39234-82-7 4-Nitro-3-trifluormethylthiophenol 
• 393-09-9 4-fluoro-1-nitro-2-trifluoromethyl-benzene 
• 401-80-9 3-fluoro-trifluoromethylbenzene 

Downstream Products

• 39234-84-9 4-amino-3-trifluoromethylbenzenesulfonamide 
• 1254718-85-8 (S)-tert-butyl 1-(4-nitro-3-(trifluoromethyl)phenylsulfonyl)pyrrolidine-2-carboxylate 
• 1217511-91-5 4-(4-nitro-3-trifluoromethylphenylsulfamoyl)benzoic acid methyl ester 

Relevant academic research and scientific papers

Development of nonsteroidal antiandrogens: 4-Nitro-3-trifluoro-methyldiphenylamines

For the development of new nonsteroidal antiandrogens a series of 4-nitro-3-trifluoromethyldiphenylamines was synthesized and compounds were tested for their affinities to steroid hormone receptors and for antiandrogenic activities. These compounds were synthesized by reacting 4-nitro-3-trifluoromethylphenylsulfocyanamide-sodium (4) with the corresponding aromatic amines to give the N-(4-nitro-3-trifluoromethylphenylsulfonyl)-N'-phenylguanidines. The crude products were then converted to the desired diphenylamines by Smiles rearrangement and hydrolysis. 2-Hydroxy-4'-nitro-3'-trifluoromethyldiphenylamine (13), which shows a relative binding affinity (RBA) to the androgen receptor (AR) of 6.5% of that of testosterone, exerts a higher affinity than hydroxyflutamide (RBA = 4.5). Shift of the hydroxy-function to position 3 or 4 as well as N-methylation caused a decrease in AR-affinity. Compounds exerting AR-affinity were tested for antiandrogenic activity. Compound 13 showed the best antiandrogenic effect, though less than the well-known antiandrogen flutamide.

Cycloalkanecarboxanilide derivative herbicides

Certain cycloalkanecarboxanilide derivatives are useful as herbicides.

Substituted benzenesulfonamides as anthelmintics

This invention relates to a novel method for the treatment of parasitic diseases and the compositions used in said treatment. More specifically this invention relates to benzenesulfonamides substituted at the 3, 4, and 5 positions of the benzene ring and to the use of such compounds for the treatment of mature and immature liver fluke infections.