39238-09-0

Basic information

• Product Name: 5-(chloroMethyl)furan-2-carboxylic acid
• Synonyms: 5-(chloroMethyl)furan-2-carboxylic acid;2-Furancarboxylic acid, 5-(chloroMethyl)-
• CAS NO: 39238-09-0
• Molecular Formula: C₆H₅ClO₃
• Molecular Weight: 160.5551
• Mol File: 39238-09-0.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 5-(chloroMethyl)furan-2-carboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(chloroMethyl)furan-2-carboxylic acid(39238-09-0)
• EPA Substance Registry System: 5-(chloroMethyl)furan-2-carboxylic acid(39238-09-0)

Safety Data

• Hazardous Substances Data: 39238-09-0(Hazardous Substances Data)

Upstream product

• 6338-41-6 5-hydroxymethyl-furan-2-carboxylic acid 
• 13529-17-4 5-Formyl-2-furancarboxylic acid 
• 57-48-7 D-Fructose 
• 1623-88-7 5-chloromethylfurfural 

Downstream Products

• 934-65-6 5-(aminomethyl)furan-2-carboxylic acid 
• 51521-95-0 5-aminomethyl-2-furancarboxylic acid hydrochloride salt 
• 330826-84-1 C₁₅H₁₆O₄ 
• 160938-85-2 N-(Boc)-5-aminomethyl-2-furoic acid 
• 1027167-05-0 5-[(R)-2-Cyano-2-((S)-2-diphenylacetylamino-3-m-tolyl-propionylamino)-ethoxymethyl]-furan-2-carboxylic acid allyl ester 
• 1027076-55-6 5-[2-(2-tert-butoxycarbonylamino-3-m-tolyl-propionylamino)-2-cyano-ethoxymethyl]-furan-2-carboxylic acid allyl ester 
• 1026055-75-3 5-[(R)-2-((S)-2-Amino-3-m-tolyl-propionylamino)-2-cyano-ethoxymethyl]-furan-2-carboxylic acid allyl ester 
• 2144-37-8 methyl 5-(chloromethyl)-2-furoate 

Relevant articles and documents

Preparation method of N-4-indolyl-2-furoylamide compound

The invention relates to the technical field of organic synthesis and medicine synthesis, in particular to a preparation method of an N-4-indolyl-2-furoylamide compound. The preparation method comprises the following steps: taking 2-mercapto-4,6-dimethyl pyrimidine as an initial raw material, carrying out substitution reaction on the 2-mercapto-4,6-dimethyl pyrimidine and 5-chloromethyl furan-2-formic acid, and then carrying out condensation reaction on the obtained product and 4-aminoindole to synthesize an N-4-indolyl-2-furoylamide compound. The N-4-indolyl-2-furanformamide compound disclosed by the invention is 5-(((4, 6-dimethyl pyrimidine-2-thiol) methyl)-N-(1H-indolyl-4-yl) furan-2-formamide. The raw materials which are low in cost and easy to obtain are adopted, the whole reaction route is mild, operation is easy, harsh reaction conditions are not needed, most of the reaction processes are carried out at room temperature, the yield of the N-4-indolyl-2-furoylamide compound is high, and the N-4-indolyl-2-furoylamide compound has potential BTK inhibitory activity and has good application prospects in medicine research and development.

OXIDATION CHEMISTRY ON FURAN ALDEHYDES

Provided herein are methods of producing halomethylfuroic and acyloxymethylfuroic acid and ester compounds from furfural starting compounds. For example, 5-chloromethyl-2-furoic acid may be produced from 5-chloromethylfurfural, in the presence of various oxidants. Salts of the furoic acids may also be produced.

Cyclic trimer of 5-(aminomethyl)-2-furancarboxylic acid as a novel synthetic receptor for carboxylate recognition

A novel 18-membered cyclic oligopeptide 1 based on 5-(aminomethyl)-2-furancarboxylic acid (2), is developed as an excellent receptor for carboxylate binding having an association constant of 8.64×103 M-1 for tetrabutylammonium acetate in CD3CN. The synthesis of 1 was achieved by a high-yielding cyclotrimerization reaction of the unfunctionalized furan amino acid 2.