39267-45-3

Basic information

• Product Name: Benzenamine, 2,4,6-trimethyl-N-(2-methylphenyl)-
• Synonyms: 2,4,6-trimethyl-N-ortho-tolylaniline;Benzenamine,2,4,6-trimethyl-N-(2-methylphenyl);2,2',4,6-Tetramethyldiphenylamin;2,2',4,6,6'-pentamethyldiphenylamine;N-(o-Tolyl)-2.4.6-trimethylanilin;N-(2-methylphenyl)-2,4,6-trimethylaniline;2,4,6-trimethyl-N-(o-tolyl)aniline
• CAS NO: 39267-45-3
• Molecular Formula: C16H19N
• Molecular Weight: 225.334
• Mol File: 39267-45-3.mol
• Article Data: 18

Chemical Properties

• CAS DataBase Reference: Benzenamine, 2,4,6-trimethyl-N-(2-methylphenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzenamine, 2,4,6-trimethyl-N-(2-methylphenyl)-(39267-45-3)
• EPA Substance Registry System: Benzenamine, 2,4,6-trimethyl-N-(2-methylphenyl)-(39267-45-3)

Safety Data

• Hazardous Substances Data: 39267-45-3(Hazardous Substances Data)

Upstream product

• 31656-92-5 1-azido-2-methyl-benzene 
• 108-67-8 1,3,5-trimethyl-benzene 
• 576-83-0 2,4,6-trimethylphenyl bromide 
• 95-53-4 o-toluidine 
• 615-37-2 ortho-methylphenyl iodide 
• 88-05-1 2,4,6-trimethylaniline 
• 1667-04-5 2-bromomesitylene 
• 95-49-8 2-methylchlorobenzene 
• 95-46-5 2-methylphenyl bromide 

Relevant articles and documents

Synthesis of N-heterocyclic carbene-Pd(II)-5-phenyloxazole complexes and initial studies of their catalytic activity toward the Buchwald-Hartwig amination of aryl chlorides

Three new N-heterocyclic carbene (NHC)-Pd(II) complexes using 5-phenyloxazole as the ancillary ligand have been obtained in moderate to good yields by a one-pot reaction of the corresponding imidazolium salts, palladium chloride and 5-phenyloxazole under mild conditions. Initial studies showed that one of the complexes is an efficient catalyst for the Buchwald-Hartwig amination of aryl chlorides with various secondary and primary amines under the varied catalyst loading of 0.01-0.05 mol%, thus it will enrich the chemistry of NHCs and give an alternative catalyst for the coupling of challenging while cost-low aryl chlorides.

Stable, Well-Defined Nickel(0) Catalysts for Catalytic C-C and C-N Bond Formation

The synthesis and catalytic activity of several classes of NHC-Ni(0) precatalysts stabilized by electron-withdrawing alkenes are described. Variations in the structure of fumarate and acrylate ligands modulate the reactivity and stability of the NHC-Ni(0) precatalysts and lead to practical and versatile catalysts for a variety of transformations. The catalytic activity and efficiency of representative members of this class of catalysts have been evaluated in reductive couplings of aldehydes and alkynes and in N-arylations of amines.

Synthesis of N-heterocyclic carbene-Pd(II) complexes and their catalytic activity in the Buchwald-Hartwig amination of aryl chlorides

Novel N-heterocyclic carbene-palladium(II) complexes using 2-picolinic acid as the ancillary ligand have been successfully developed under mild conditions. Their catalytic activity in organic synthesis has been initially tested in the Buchwald-Hartwig amination of secondary and primary amines with aryl chlorides. Various substituents on both substrates can be tolerated, giving the desired coupling products in good to almost quantitative yields. The minimum catalyst loading can be 0.01 mol%, implying their potential application toward industrial processes.