392692-67-0Relevant articles and documents
Synthesis of the EF fragment of spongistatin 1
Kawahara, Shigeru,Gaunt, Matthew J.,Scolaro, Alessandra,Yamanoi, Shigeo,Ley, Steven V.
, p. 2031 - 2034 (2007/10/03)
The EF fragment of spongistatin 1 was prepared diastereoselectively from 3,4,5-tri-O-benzyl-D-glucal. Georg Thieme Verlag Stuttgart.
Stereocontrolled total synthesis of (+)-altohyrtin A/spongistatin 1
Paterson, Ian,Chen, David Y.-K.,Coster, Mark J.,Acea, Jose L.,Bach, Jordi,Gibson, Karl R.,Keown, Linda E.,Oballa, Renata M.,Trieselmann, Thomas,Wallace, Debra J.
, p. 4055 - 4060 (2007/10/03)
As an exceptionally potent antimitotic macrolide, altohyrtin A/spongistatin 1 shows great promise in cancer chemotherapy but its extreme scarcity in the natural sponges has halted its further preclinical development. A highly stereocontrolled total synthe