393134-67-3

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• 7311-34-4 3,5-dimethoxybenzaldehdye 
• 88-74-4 2-nitro-aniline 
• 95-54-5 1,2-diamino-benzene 
• 39151-19-4 1-(3,5-dimethoxyphenyl)ethan-1-one 

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• 1447946-63-5 C₂₉H₂₂N₂O₂ 

Relevant academic research and scientific papers

Visible-light-induced condensation cyclization to synthesize benzimidazoles using fluorescein as a photocatalyst

A mild strategy for visible-light-induced synthesis of benzimidazoles was developed using aromatic aldehydes and o-phenylenediamines as substrates. The use of an organic dye, fluorescein, as an innoxious photocatalyst provided a mild and inexpensive catalytic system to synthesize a series of benzimidazoles in moderate to excellent yields. It was originally applied to this system to obtain benzimidazoles. Besides, the catalytic system does not require an additional oxidant or metal which was good for the environment.

s-Tetrazine-functionalized hyper-crosslinked polymers for efficient photocatalytic synthesis of benzimidazoles

Developing green-safe, efficient and recyclable catalysts is crucial for the chemical industry. So far, organic photocatalysis has been proved to be an environmentally friendly and energy-efficient synthetic technology compared with traditional metal catalysis. As a versatile catalytic platform, hyper-crosslinked polymers (HCPs) with large surface area and high stability are easily prepared. In this report, we successfully constructed two porous HCP photocatalysts (TZ-HCPs) featurings-tetrazine units and surface areas larger than 700 m2g?1through Friedel-Crafts alkylation reactions. The rational energy-band structures and coexisting micro- and mesopores endow TZ-HCPs with excellent activities to realize the green synthesis of benzimidazoles (28 examples, up to 99% yield, 0.5-4.0 h) in ethanol. Furthermore, at least 21 iterative catalytic runs mediated by TZ-HCP1D were performed efficiently, with 96-99% yield. This study of TZ-HCPs sheds light on the wide-ranging prospects of application of HCPs as metal-free and green photocatalysts for the preparation of fine chemicals.

Reusable nano-zirconia-catalyzed synthesis of benzimidazoles and their antibacterial and antifungal activities

In this article, a zirconia-based nano-catalyst (Nano-ZrO2 ), with intermolecular C-N bond formation for the synthesis of various benzimidazole-fused heterocycles in a concise method is reported. The robustness of this reaction is demonstrated

Solvent-dependent metal-free chemoselective synthesis of benzimidazoles and 1,3,5-triarylbenzenes from 2-amino anilines and aryl alkyl ketones catalyzed by I2

A solvent-dependent I2-catalyzed chemoselective reaction was developed for the synthesis of benzimidazoles and 1,3,5-triarylbenzenes via the annulation of 2-amino anilines and aryl alkyl ketones or the cyclization of aryl alkyl ketones, respectively. With 1,4-dioxane as the solvent, sequential C[sbnd]N bond formation followed by C(CO)-C(CH3) bond cleavage leads to the formation of benzimidazoles in a highly selective manner while aldol-type self-condensation of aryl alkyl ketones predominates using PhNO2 or PhCl as the solvent to afford 1,3,5-triarylbenzenes.

Green synthesis of benzimidazole derivatives catalyzed by ionic liquid under microwave irradiation

An efficient synthesis of benzimidazole derivatives from o-phenylene diamine and substituted aromatic aldehyde catalyzed by ionic liquid under microwave irradiation was reported. The synthesis conditions were first optimized by single factor experiments. Then, a central composite design combined with response surface methodology was used to study the most effective factors. Optimal conditions were synthesis time 1 h, the reactant/catalyst molar ratio 1:1:0.200, the temperature 50 °C and the microwave power 500 W. Under optimized conditions, the yields of benzimidazole derivatives were 78.55-97.66 %. This method offered the outstanding advantages, such as faster reaction rate, higher yields, recyclable catalyst, environmental friendliness, and simple workup procedure.

Synthesis of 2-substituted benzimidazoles in the presence of polyaniline nanoparticles doped with 12-tungstophosphoric acid as reusable heterogeneous catalyst

Polyaniline nanoparticles doped with 12-tungstophosphoric acid was prepared with different loading amounts of 12-tungstophosphoric acid. Doped polyaniline was characterized by XRD, SEM, and FT-IR techniques and the Keggin anion of heteropoly acid was dete

A green synthesis of benzimidazoles

Various 2-substituted benzimidazole derivatives in moderate to good yield have been prepared in a one-pot reaction by condensation of o-phenylenediamine and an aldehyde in the presence of ammonium chloride as a catalyst at 80-90°C. The reaction is green and economically viable.

FeCl3-doped polyaniline nanoparticles as reusable heterogeneous catalyst for the synthesis of 2-substituted benzimidazoles

FeCl3-doped polyaniline nanoparticles efficiently catalyze the synthesis of 2-substituted benzimidazoles by the reaction of aldehydes with o-phenylenediamine. Synthesis and characterization of the catalyst are described, and the obtained results confirms good dispersion of the FeCl3 on the polyaniline. Simple workup, mild reaction conditions, low cost, easy separation, and reusability of the catalyst are some advantages of this method.

Synthesis of benzimidazoles and benzoxazoles using palladium bis(2,2,6,6-tetramethyl-3,5-heptanedionate) as a novel catalyst

Structurally well-defined palladium bis(2,2,6,6-tetramethyl-3,5- heptanedionate) complex is reported to be an efficient catalyst for the synthesis of benzimidazole and benzoxazole derivatives in good yields. A novel approach for one-pot synthesis of benzimidazoles via direct reductive amination and N-arylation followed by hydrogenation-cyclization methodology is also described. Copyright