393165-20-3

Usage

Uses

Used in Pharmaceutical Industry:
(Z)-N-hydroxy-4-fluoro-benzenecarboximidoyl chloride is used as a reagent for the production of various drugs. Its ability to form bonds with nitrogen and oxygen atoms makes it a valuable building block for complex organic molecules, which are essential in the development of new pharmaceuticals.
Used in Organic Synthesis:
In the field of organic synthesis, (Z)-N-hydroxy-4-fluoro-benzenecarboximidoyl chloride is used as a key component in the formation of amides and imidoyl chlorides. Its unique structure allows for the creation of a wide range of chemical compounds with diverse applications.
Used in the Synthesis of Bioactive Compounds:
(Z)-N-hydroxy-4-fluoro-benzenecarboximidoyl chloride is also utilized in the synthesis of bioactive and medicinally relevant compounds due to its potential to facilitate the creation of molecules with significant biological activity. This makes it a crucial component in the development of new drugs and therapies.

Upstream product

• 459-23-4 (E)-4-fluorobenzaldehyde oxime 
• 459-23-4 4-fluorobenzaldoxime 
• 459-57-4 4-fluorobenzaldehyde 
• 588-95-4 syn-4-fluorobenzaldoxime 

Downstream Products

• 49750-46-1 p-fluorobenzonitrile oxide 
• 673451-63-3 C₁₇H₁₄FN₃O₃S 
• 159693-06-8 3-(4-fluoro-phenyl)-isoxazole-4-carboxylic acid ethyl ester 
• 954230-39-8 3-(4-fluoro-phenyl)-5-methyl-isoxazole-4-carboxylic acid ethyl ester 
• 1018297-63-6 [3-(4-fluoro-phenyl)-5-methyl-isoxazol-4-yl]-methanol 
• 1159600-30-2 6-[3-(4-fluoro-phenyl)-5-methyl-isoxazol-4-ylmethoxy]-nicotinic acid methyl ester 
• 1159600-32-4 6-[3-(4-fluoro-phenyl)-5-methyl-isoxazol-4-ylmethoxy]-nicotinic acid 
• 1736-21-6 3-(4-fluoro-phenyl)-5-methyl-isoxazole-4-carboxylic acid 
• 1422283-24-6 3-(3-(4-fluorophenyl)isoxazol-5-yl)propanoic acid 
• 125160-90-9 3-(p-fluorophenyl)-5-(γ-hydroxypropyl)isoxazole 
• 1615228-56-2 N-benzyl-2-(2-(4-fluorophenyl)-2-oxoacetamido)-N-methylacetamide 
• 238743-27-6 N-[[4,5-dihydro-3-[4-fluorophenyl]-5-isoxazolyl]methyl]acetamide 
• 491875-99-1 3-(4-fluoro-phenyl)-5-methylisoxazole 

Relevant academic research and scientific papers

Leaving Group Assisted Strategy for Photoinduced Fluoroalkylations Using N-Hydroxybenzimidoyl Chloride Esters

Redox-active esters (RAEs) as alkyl radical precursors have been extensively developed for C?C bond formations. However, the analogous transformations of fluoroalkyl radicals from the corresponding acid or ester precursors remain challenging because of the high oxidation potential of the fluoroalkyl carboxylate anions. The newly developed N-hydroxybenzimidoylchloride (NHBC) ester provides a general leaving group assisted strategy to generate a portfolio of fluoroalkyl radicals, and can be successfully applied in photoinduced decarboxylative hydrofluoroalkylation and heteroarylation of unactivated olefins. In addition, DFT calculations revealed that the NHBC ester proceeds by the fluorocarbon radical pathway, whereas other well-known RAEs proceed by the nitrogen radical pathway.

(1aR,12bS)-8-cyclohexyl-11-fluoro-N-((1-methylcyclopropyl)sulfonyl)-1a-((3-methyl-3,8-diazabicyclo[3.2.1]oct-8-yl)carbonyl)-1,1a,2,2b-tetrahydrocyclopropa[d]indolo[2,1-a][2]benzazepine-5-carboxamide for use in treating HCV

The invention relates to an administration unit comprising a compound of formula and/or pharmaceutically acceptable salts thereof, and to a packaging comprising the administration unit according to the invention.

Reaction between (Z)-Arylchlorooximes and α-Isocyanoacetamides: A procedure for the synthesis of Aryl-α-ketoamide amides

(Z)-Arylchlorooximes and α-isocyanoacetamides undergo a smooth reaction to produce 1,3-oxazol-2-oxime derivatives in good yields. Opening of the oxazole ring and deoximation reaction give a facile access to aryl-α-ketoamide amides, a class of privileged s

ISOXAZOLO-PYRIDAZINE DERIVATIVES

The invention relates to isoxazolo-pyridazine compounds, in particular those of formula I as described above and to a pharmaceutically acceptable salts thereof, having affinity and selectivity for the GABA A α5 receptor binding site, their manufacture, pharmaceutical compositions containing them and their use as cognitive enhancers or for the treatment of cognitive disorders like Alzheimer's disease.

ISOXAZOLES AND THEIR USE IN THE TREATMENT OF ISCHEMIC DISEASES

The present invention provides a compound of formula I, or a pharmaceutically acceptable salt thereof. These compounds are useful for the treatment of neurological, neurodegenerative, ischemic and inflammatory disorders. Accordingly, the invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of utilizing those compounds and compositions in the treatment of neurological, neurodegenerative, ischemic and inflammatory disorders.

SUBSTITUTED AMINOPHENYL ISOXAZOLINE DERIVATIVES USEFUL AS ANTIMICROBIALS

The present invention provides novel substituted amionphenyl isoxazoline derivatives of formula I wherein R1 is H, alkyl, cycloalkyl, alkoxy, amino, or alkylamino; X and Y are the same and different and are H, F, or CH3; W is O, or S; Q is a 4-, 5-, 6-, 7-, or 9-membered heterocyclic moiety containing one or more nitrogen, sulfur and/or oxygen. The compounds of the invention are useful as antimicrobial agents for preventing and treating infectious diseases.

Substituted aminophenyl isoxazoline derivatives useful as antimicrobials

The present invention provides novel substituted amionphenyl isoxazoline derivatives of formula I STR1 wherein R1 is H, alkyl, cycloalkyl, alkoxy, amino, or alkylamino; X and Y are the same and different and are H, F, or CH3 ; W is O, or S; Q is a 4-, 5-, 6-, 7-, or 9-membered heterocyclic moiety containing one or more nitrogen, sulfur and/or oxygen. The compounds of the invention are useful as antimicrobial agents for preventing and treating infectious diseases.