393570-36-0Relevant academic research and scientific papers
Trisubstituted acridine derivatives as potent and selective telomerase inhibitors
Harrison, R. John,Cuesta, Javier,Chessari, Gianni,Read, Martin A.,Basra, Sanji K.,Reszka, Anthony P.,Morrell, James,Gowan, Sharon M.,Incles, Christopher M.,Tanious, Farial A.,Wilson, W. David,Kelland, Lloyd R.,Neidle, Stephen
, p. 4463 - 4476 (2003)
The synthesis and evaluation for telomerase-inhibitory and quadruplex DNA binding properties of three related series of rationally designed trisubstituted acridine derivatives are described. These are substituted on the acridine ring at the 2,6,9; 2,7,9;
Therapeutic acridone and acridine compounds
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Page/Page column 54, (2008/06/13)
The present invention pertains to acridone and acridine compounds of formula (I), wherein either: (a) K is ═O, L is —H, alpha is a single bond, beta is a double bond, gamma is a single bond (acridones); or, (b) K is a 9-substituent, L is absent, alpha is
