393589-26-9

Basic information

• Product Name: 2-(5-{2-(tert-butyl-dimethyl-silanyloxy)-3-[5-(2-dimethylamino-pentyl)-tetrahydro-furan-2-yl]-1-methyl-butyl}-tetrahydro-furan-2-yl)-propionic acid 1-[5-(1-benzyloxycarbonyl-ethyl)-tetrahydro-furan-2-ylmethyl]-butyl ester
• Synonyms: 2-(5-{2-(tert-butyl-dimethyl-silanyloxy)-3-[5-(2-dimethylamino-pentyl)-tetrahydro-furan-2-yl]-1-methyl-butyl}-tetrahydro-furan-2-yl)-propionic acid 1-[5-(1-benzyloxycarbonyl-ethyl)-tetrahydro-furan-2-ylmethyl]-butyl ester
• CAS NO: 393589-26-9
• Molecular Weight: 830.274
• Mol File: 393589-26-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-(5-{2-(tert-butyl-dimethyl-silanyloxy)-3-[5-(2-dimethylamino-pentyl)-tetrahydro-furan-2-yl]-1-methyl-butyl}-tetrahydro-furan-2-yl)-propionic acid 1-[5-(1-benzyloxycarbonyl-ethyl)-tetrahydro-furan-2-ylmethyl]-butyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(5-{2-(tert-butyl-dimethyl-silanyloxy)-3-[5-(2-dimethylamino-pentyl)-tetrahydro-furan-2-yl]-1-methyl-butyl}-tetrahydro-furan-2-yl)-propionic acid 1-[5-(1-benzyloxycarbonyl-ethyl)-tetrahydro-furan-2-ylmethyl]-butyl ester(393589-26-9)
• EPA Substance Registry System: 2-(5-{2-(tert-butyl-dimethyl-silanyloxy)-3-[5-(2-dimethylamino-pentyl)-tetrahydro-furan-2-yl]-1-methyl-butyl}-tetrahydro-furan-2-yl)-propionic acid 1-[5-(1-benzyloxycarbonyl-ethyl)-tetrahydro-furan-2-ylmethyl]-butyl ester(393589-26-9)

Safety Data

• Hazardous Substances Data: 393589-26-9(Hazardous Substances Data)

Upstream product

• 364597-69-3 benzyl (2S,3R,6S,8S)-3,6-epoxy-8-hydroxy-2-methylundecanoate 
• 393589-25-8 (R)-2-((2R,5S)-5-{(1R,2S,3R)-2-(tert-Butyl-dimethyl-silanyloxy)-3-[(2R,5S)-5-((R)-2-dimethylamino-pentyl)-tetrahydro-furan-2-yl]-1-methyl-butyl}-tetrahydro-furan-2-yl)-propionic acid 
• 393589-24-7 (R)-2-((2R,5S)-5-{(1R,2S,3R)-2-(tert-Butyl-dimethyl-silanyloxy)-3-[(2R,5S)-5-((R)-2-dimethylamino-pentyl)-tetrahydro-furan-2-yl]-1-methyl-butyl}-tetrahydro-furan-2-yl)-propionic acid methyl ester 
• 365498-73-3 (1S,2S,5S,7R)-2-Methyl-5-propyl-4,10-dioxa-bicyclo[5.2.1]decan-3-one 
• 100-51-6 benzyl alcohol 
• 158355-82-9 2-(5-<3-<5-(2-dimethylamino-pentyl)tetrahydro-furan-2-yl>-2-hydroxy-1-methyl-butyl>tetrahydro-furan-2-yl)propionic acid methyl ester 
• 69739-34-0 t-butyldimethylsiyl triflate 

Downstream Products

• 100905-89-3 pamamycin-607 
• 393589-27-0 (R)-2-((2R,5S)-5-{(1S,2S,3S)-3-[(2R,5S)-5-((R)-2-Dimethylamino-pentyl)-tetrahydro-furan-2-yl]-2-hydroxy-1-methyl-butyl}-tetrahydro-furan-2-yl)-propionic acid (S)-1-[(2S,5R)-5-((S)-1-benzyloxycarbonyl-ethyl)-tetrahydro-furan-2-ylmethyl]-butyl ester 

Relevant articles and documents

Total synthesis of pamamycin-607

The macrodiolide antibiotic pamamycin-607 has been synthesized by coupling of the two hydroxy acid constituents using the Yamaguchi method. While the final lactonization with formation of the ester linkage between C(1) and the C(8′) oxygen proceeded with complete C(2) epimerization, the alternative ring closure involving the carboxylic acid of the smaller fragment and the hydroxyl group of the larger fragment yielded the target molecule.