394-66-1 Usage
Uses
Used in Pharmaceutical Synthesis:
5-Fluoroisoquinoline is used as a key intermediate in the synthesis of pharmaceuticals for its ability to enhance the biological activity of drug molecules. The fluorine atom in its structure can improve the pharmacokinetic and pharmacodynamic properties of the resulting compounds, leading to more effective medications.
Used in Agrochemical Production:
In the agrochemical industry, 5-Fluoroisoquinoline is utilized as a building block for the development of new agrochemicals. Its unique properties can contribute to the creation of more potent and selective pesticides or herbicides, thereby increasing agricultural productivity and crop protection.
Used in Fine Chemicals Synthesis:
5-Fluoroisoquinoline is employed as a precursor in the synthesis of various fine chemicals, where its specific structural features can be leveraged to produce specialty chemicals with tailored properties for use in different industries.
Used in Drug Design and Discovery:
5-Fluoroisoquinoline is used as a structural component in drug design and discovery, where its presence can modulate the activity of drug candidates. The fluorine substitution can affect the lipophilicity, metabolic stability, and receptor binding affinity of molecules, making it a valuable tool in medicinal chemistry.
Used in the Production of Novel Materials and Dyes:
5-Fluoroisoquinoline is utilized as a precursor in the development of innovative materials and dyes, where its chemical structure can impart specific characteristics such as color, stability, or reactivity to the final products.
Check Digit Verification of cas no
The CAS Registry Mumber 394-66-1 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 3,9 and 4 respectively; the second part has 2 digits, 6 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 394-66:
(5*3)+(4*9)+(3*4)+(2*6)+(1*6)=81
81 % 10 = 1
So 394-66-1 is a valid CAS Registry Number.
394-66-1Relevant academic research and scientific papers
PhenoFluorMix: Practical chemoselective deoxyfluorination of phenols
Fujimoto, Teppei,Ritter, Tobias
supporting information, p. 544 - 547 (2015/03/05)
A practical deoxyfluorination with novel deoxyfluorinating reagent PhenoFluorMix, a mixture of N,N'-1,3-bis(2,6-diisopropylphenyl)chloroimidazolium chloride and CsF, is presented. PhenoFluorMix overcomes the challenges associated with hydrolysis of PhenoFluor. PhenoFluorMix does not hydrolyze, is readily available on decagram scale, and is storable in air. In this paper, we demonstrate the practicality of the reagent and exhibit the deoxyfluorination of a variety of phenols and heterocycles.
FLUORINATION OF ORGANIC COMPOUNDS
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Paragraph 00207, (2015/05/05)
Methods for fluorinating organic compounds utilizing a novel organic reagent are described herein. The invention further discloses the utility of this reagent for incorporation of the 18 F isotope into hydroxyl group -containing organic molecules for PET imaging studies. Preparation of the reagents is described along with isolable intermediate structures from reaction of the reagent with a hydroxyl group-containing organic molecule.
PhenoFluor: Practical synthesis, new formulation, and deoxyfluorination of heteroaromatics
Fujimoto, Teppei,Becker, Fabian,Ritter, Tobias
supporting information, p. 1041 - 1044 (2014/11/07)
We report a practical synthesis method of the reagent PhenoFluor on decagram scale, provide a new formulation of PhenoFluor as a toluene solution, which should decrease challenges associated with the moisture sensitivity of the reagent, and expand the substrate scope of deoxyfluorination with PhenoFluor to heteroaromatics.
