394223-70-2Relevant academic research and scientific papers
Inhibitors of DNA polymerase β from Schoepfia californica
Chen, Jie,Zhang, Yu-Huan,Wang, Li-Kai,Sucheck, Steven J.,Snow, Angela M.,Hecht, Sidney M.
, p. 2769 - 2770 (1998)
Fractionation of a hexane extract prepared from the plant Schoepfia californica was carried out by bioassay guided fractionation, affording five inhibitors of DNA polymerase β; four of these were shown to be anacardic acid and structurally related derivatives, while the fifth was oleic acid.
Total synthesis of 6-deoxydihydrokalafungin, a key biosynthetic precursor of actinorhodin, and its epimer
Ichinose, Koji,Kainuma, Mika,Katakawa, Kazuaki,Kumamoto, Takuya,Matsuo, Yoshika,Taguchi, Takaaki,Takahashi, Azusa
, (2021/10/26)
In this article, we report the total synthesis of 6-deoxydihydrokalafungin (DDHK), a key biosynthetic intermediate of a dimeric benzoisochromanequinone antibiotic, actinorhodin (ACT), and its epimer, epi-DDHK. Tricyclic hemiacetal with 3-siloxyethyl group was subjected to Et3SiH reduction to establish the 1,3-cis stereochemistry in the benzoisochromane, and a subsequent oxidation/deprotection sequence then afforded epi-DDHK. A bicyclic acetal was subjected to AlH3 reduction to deliver the desired 1,3-trans isomer in an approximately 3:1 ratio, which was subjected to a similar sequence to that used for the 1,3-cis isomer that successfully afforded DDHK. A semisynthetic approach from (S)-DNPA, an isolable biosynthetic precursor of ACT, was also examined to afford DDHK and its epimer, which are identical to the synthetic products.
NITROGEN-CONTAINING BICYCLIC HETEROCYCLES FOR USE AS ANTIBACTERIALS
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Page/Page column 57, (2010/02/07)
Cyclohexane and cyclohexene derivatives and pharmaceutically acceptable derivatives hereof useful in methods of treatment of bacterial infections in mammals, particularly man.
