394237-61-7

Usage

General Description

1,3-Benzenediol, 4-[4-(4-methoxyphenyl)-5-methyl-1H-pyrazol-3-yl]- is a chemical compound with a complex molecular structure. It is composed of a benzene ring with two hydroxyl groups and a pyrazole ring attached to it. The benzene ring contains a methoxyphenyl group and a methyl group, while the pyrazole ring has a 4-hydroxy group. 1,3-Benzenediol, 4-[4-(4-methoxyphenyl)-5-methyl-1H-pyrazol-3-yl]- may have potential applications in pharmaceuticals, as it exhibits biological activity and may have therapeutic properties. Its precise uses and effects would need further research and investigation.

Upstream product

• 108-46-3 recorcinol 
• 104-01-8 4-Methoxyphenylacetic acid 

Relevant academic research and scientific papers

Repurposing Hsp90 inhibitors as antibiotics targeting histidine kinases

To address the growing need for new antimicrobial agents, we explored whether inhibition of bacterial signaling machinery could inhibit bacterial growth. Because bacteria rely on two-component signaling systems to respond to environmental changes, and because these systems are both highly conserved and mediated by histidine kinases, inhibiting histidine kinases may provide broad spectrum antimicrobial activity. The histidine kinase ATP binding domain is conserved with the ATPase domain of eukaryotic Hsp90 molecular chaperones. To find a chemical scaffold for compounds that target histidine kinases, we leveraged this conservation. We screened ATP competitive Hsp90 inhibitors against CckA, an essential histidine kinase in Caulobacter crescentus that controls cell growth, and showed that the diaryl pyrazole is a promising scaffold for histidine kinase inhibition. We synthesized a panel of derivatives and found that they inhibit the histidine kinases C. crescentus CckA and Salmonella PhoQ but not C. crescentus DivJ; and they inhibit bacterial growth in both Gram-negative and Gram-positive bacterial strains.