394253-88-4

Upstream product

• 209784-85-0 [2-(4-aminomethylbenzoylamino)phenyl]carbamic acid tert-butyl ester 
• 1392327-85-3 tert-butyl N-(2-([4-(chloromethyl)benzoyl]amino)phenyl)carbamate 
• 876-08-4 p-(chloromethyl)benzoyl chloride 
• 146651-75-4 tert–butyl (2–aminophenyl)carbamate 
• 33233-67-9 4-(tert-Butoxycarbonylaminomethyl)benzoic acid 
• 391244-48-7 [4-(2-aminophenylcarbamoyl)benzyl]carbamic acid tert-butyl ester 
• 95-54-5 1,2-diamino-benzene 
• 239120-55-9 N-(2-aminophenyl)-4-cyanobenzamide 

Downstream Products

• 1141446-18-5 3-(3,4-dimethoxyphenyl)-2-(4-methoxyphenyl)allyl-4-(2-aminophenylcabamoyl) benzylcarbamate 
• 1141444-84-9 N-(2-aminophenyl)-4-((3-(3,4-difluorophenyl)-2-(4-fluorophenyl)acrylamido)methyl)benzamide 
• 1415340-63-4 N-(2-aminophenyl)-4-[(4-methylene-1-oxo-3,4-dihydroisoquinolin-2(1H)-yl)methyl]benzamide 
• 1221412-06-1 3-(acetylamino)-N-(4-{[(2-aminophenyl)amino]carbonyl}benzyl)adamantane-1-carboxamide 

Relevant academic research and scientific papers

Image-guided synthesis reveals potent blood-brain barrier permeable histone deacetylase inhibitors

Recent studies have revealed that several histone deacetylase (HDAC) inhibitors, which are used to study/treat brain diseases, show low blood-brain barrier (BBB) penetration. In addition to low HDAC potency and selectivity observed, poor brain penetrance

N- (2 -AMINOPHENYL) BENZAMIDE DERIVATIVES AS HISTONE DEACETYLASE INHIBITORS

This invention relates to the discovery of novel compounds, or pharmaceutically acceptable salts thereof, which possess HDAC inhibitory activity. In particular, the compounds of the invention demonstrate selectivity towards Class I HDAC enzymes, and are a

N- (2 -AMINOPHENYL) BENZAMIDE DERIVATIVES AS HISTONE DEACETYLASE INHIBITORS

This invention relates to the discovery of novel compounds, or pharmaceutically acceptable salts thereof, which possess HDAC inhibitory activity. In particular, the compounds of the invention demonstrate selectivity towards Class I HDAC enzymes, and are a

NAPHTHALENE CARBOXAMIDE DERIVATIVES AS INHIBITORS OF PROTEIN KINASE AND HISTONE DEACETYLASE, PREPARATION METHODS AND USES THEREOF

The naphthalene carboxamide derivatives, the preparation methods and the uses thereof are provided. The structure thereof is shown as the formula (I), wherein the definitions of R1, R2, R3, R4 and Z are the same

Naphthamide Derivatives As Multi-Target Protein Kinase Inhibitors and Histone Deacetylase Inhibitors

Isolated compounds of formula I: and stereoisomers, enantiomers, diastereomers, and pharmaceutically acceptable salts thereof are described, as well as processes for production, and methods of use of these compounds and compositions thereof for the treatm