3946-40-5

Usage

Uses

Used in Organic Synthesis:
(6E)-6-[(2-hydroxybenzyl)amino]methylidenecyclohexa-2,4-dien-1-one is used as a key intermediate for the synthesis of various organic compounds due to its complex and functionalized nature. Its unique structure allows for further chemical modifications and the creation of novel molecules with potential applications in different industries.
Used in Pharmaceutical Research:
In the pharmaceutical industry, (6E)-6-[(2-hydroxybenzyl)amino]methylidenecyclohexa-2,4-dien-1-one is used as a starting material for the development of new drugs. Its complex structure and functional groups make it a promising candidate for the design and synthesis of innovative therapeutic agents.
Used in Medicinal Chemistry:
(6E)-6-[(2-hydroxybenzyl)amino]methylidenecyclohexa-2,4-dien-1-one is used as a compound of interest for further studies in medicinal chemistry. Its potential biological activities and the possibility of optimizing its structure for specific therapeutic applications make it a valuable subject for research and development.
Used in Drug Development:
In the field of drug development, (6E)-6-[(2-hydroxybenzyl)amino]methylidenecyclohexa-2,4-dien-1-one is used as a lead compound for the discovery of new pharmaceuticals. Its unique chemical structure and potential biological activities provide a foundation for the development of novel therapeutic agents with improved efficacy and safety profiles.

Upstream product

• 129855-29-4 N-(2-hydroxybenzylidene)benzylamine 
• 100-46-9 benzylamine 
• 90-02-8 salicylaldehyde 
• 94-67-7 salicylaldehyde-oxime 
• 1206675-01-5 (2-hydroxyphenyl)methanaminium acetate 
• 932-30-9 2-Hydroxybenzylamine 

Downstream Products

• 125543-78-4 Cu⁽²⁺⁾*C₆H₄(O)CHNCH₂C₆H₄(O)^(2-)={Cu(C₆H₄(O)CHNCH₂C₆H₄(O))} 
• 570370-65-9 bis(2-hydroxybenzylamine-2'-hydroxybenzylideno)tetraaquacerium(III) nitrate 

Relevant academic research and scientific papers

Synthesis of heptanuclear Ni4Dy3 coordination aggregate using tridentate ligand: X-ray structure, magnetism and theoretical studies

The Schiff base ligand, 2-(((2-hydroxybenzyl)imino)methyl)phenol (H2L) having ONO donor centres are utilized to synthesize {Ni4Dy3} coordination aggregate following the support of six benzoate bridging groups. Sequential a

Metal-free nitrogen -doped carbon nanosheets: A catalyst for the direct synthesis of imines under mild conditions

Herein, a highly stable, porous, multifunctional and metal-free catalyst was developed, which exhibited significant catalytic performance in the oxidation of amines and transfer hydrogenation of nitriles under mild conditions; this could be attributed to the presence of numerous active sites and their outstanding BET surface area. The obtained results showed that most of the yields of imines exceeded 90%, and the cycling performance of the catalyst could be at least seven runs without any decay in the reaction activity, which could be comparable to those of metal catalysts. Subsequently, a kinetic study has demonstrated that the apparent activation energy for the direct synthesis of imines from amines is 67.39 kJ mol-1, which has been performed to testify that the catalytic performances are rational. Via catalyst characterizations and experimental data, graphitic-N has been proven to be the active site of the catalyst. Hence, this study is beneficial to comprehend the mechanism of action of a metal-free N-doped carbon catalyst in the formation of imines.

Trans-Symmetric Dynamic Covalent Systems: Connected Transamination and Transimination Reactions

The development of chemical transaminations as a new type of dynamic covalent reaction is described. The key 1,3-proton shift is under complete catalytic control and can be conducted orthogonally to, or simultaneous with, transimination in the presence of an amine to rapidly yield two-dimensional dynamic systems with a high degree of complexity evolution. The transamination-transimination systems are proven to be fully reversible, stable over several days, compatible with a range of functional groups, and highly tunable. Kinetic studies show transamination to be the rate-limiting reaction in the network. Furthermore, it was discovered that readily available quinuclidine is a highly potent catalyst for aldimine transaminations. This study demonstrates how connected dynamic reactions give rise to significantly larger systems than the unconnected counterparts, and shows how reversible isomerizations can be utilized as an effective diversity-generating element. Constant exchange: The development of chemical transaminations as a new type of dynamic covalent reactions is described (see figure). This study demonstrates how connected dynamic reactions give rise to significantly larger systems than the unconnected counterparts, and shows how reversible isomerizations can be utilized as an effective diversity-generating element.

Synthesis and characterisation of aluminium(III) imine bis(phenolate) complexes with application for the polymerisation of rac-LA

A series of tridentate imine bis(phenolate) ligands have been synthesised and complexed to aluminium. Solid-state analysis identified two structural motifs of an aluminium dimer [Al2(Me)2(X)2]; one consisting of two five-c

Lanthanide(III) Complexes of ONO Donor Schiff Bases Derived from Salicylaldehyde and o-Hydroxybenzylamine or o-Aminobenzylalcohol

Several new complexes of isomeric schiff bases derived from salicylaldehyde and o-hydroxybenzylamine/o-aminobenzylalcohol with Pr(III), Nd(III), Sm(III), Gd(III), Tb(III) and Dy(III) have been synthesized and characterized by elemental analysis, molar con

New Dioxomolybdenum (VI) Complexes with Tridentate Dibasic ONO Donor Schiff Bases

Several dioxomolybdenum (VI) complexes of the schiff bases derived from salicylaldehyde, 2-hydroxy-1-naphthaldehyde, o-hydroxyacetophenone or pyridoxal and o-aminobenzylalcohol, o-aminophenol, o-hydroxybenzylamine, o-hydroxy(methylbenzyl)amine or 3-amino-