39477-38-8

Upstream product

• 583-06-2 3-benzoylacrylic acid 
• 108-98-5 thiophenol 
• 92855-45-3 4-Oxo-4-phenyl-2-phenylmercapto-butyronitril 
• 13125-52-5 3-benzoylacrylonitrile 
• 124658-46-4 2-(Diphenyl-phosphinothioylsulfanyl)-4-oxo-4-phenyl-butyric acid 
• 124658-40-8 2-(Dimethoxy-phosphoryl)-4-oxo-4-phenyl-butyric acid 
• 63104-90-5 α-bromo-β-benzoylpropionic acid 
• 92963-26-3 3-benzoyl-2-(phenylsulfanyl)propionamide 
• 17812-07-6 Benzoylacrylic acid 

Downstream Products

• 960620-33-1 benzoic acid N'-(4-oxo-4-phenyl-2-phenylsulfanyl-butyryl)-hydrazide 
• 960620-22-8 5-benzoyl-2-benzyl-4-phenylsulfanyl-isothiazol-3-one 
• 960620-40-0 C₁₇H₁₇N₃O₃S 
• 960620-15-9 N-benzyl-4-oxo-4-phenyl-2-phenylsulfanyl-butyramide 
• 960620-26-2 4-oxo-4-phenyl-2-phenylsulfanyl-butyric acid hydrazide 
• 960620-12-6 5-phenyl-3-phenylsulfanyl-3H-furan-2-one 

Relevant academic research and scientific papers

KYNURENINE 3-HYDROXYLASE INHIBITORS FOR THE TREATMENT OF DIABETES

The present invention relates to the use of at least one compound with inhibitory activity on kynurenine 3-hydroxylase for the preparation of a medicament for the prevention and/or treatment of diabetes.

ORGANOPHOSPHORUS CHEMISTRY 10. THE BEHAVIOUR OF β-AROYLACRYLIC ACIDS TOWARD NUCLEOPHILIC PHOSPHORUS COMPOUNDS

The reaction of alkyl phosphites and thiolphosphoric acids with β-aroylacrylic acids 1a,b has been investigated.Dialkyl phosphites (DAP) attacked 1 at the β-carbon atom with respect to the aroyl-carbonyl function, to give phosphonate 1:1 adducts assigned structure 2A.Thiolphosphoric acids (7) attacked 1 at the same centre to give adducts 8.On the other hand, trialkyl phosphites (TAP) converted 1 into the respective esters 5, almost exclusively.Structures of the new products were assigned according to consistent analytical and spectroscopic measurements.Key words: β-aroylacrylic acids; alkylation; phosphorylation; thiophosphorylation.