395-68-6

Basic information

• Product Name: 4-NITRO-2-(TRIFLUOROMETHYL)ACETANILIDE
• Synonyms: 2-ACETAMIDO-5-NITROBENZOTRIFLUORIDE;4'-Nitro-2'-(trifluoromethyl)acetanilide 97%;4'-Nitro-2'-(trifluoromethyl)acetanilide97%;4-NITRO-2-(TRIFLUOROMETHYL)LACETANILIDE;N1-[4-NITRO-2-(TRIFLUOROMETHYL)PHENYL]ACETAMIDE;4'-NITRO-2'-(TRIFLUOROMETHYL)ACETANILIDE;4-NITRO-2-(TRIFLUOROMETHYL)ACETANILIDE
• CAS NO: 395-68-6
• Molecular Formula: C₉H₇F₃N₂O₃
• Molecular Weight: 248.16
• Product Categories: Nitrogen Compounds;Organic Building Blocks;Protected Amines
• Mol File: 395-68-6.mol

Chemical Properties

• Melting Point: 146-150 °C(lit.)
• Boiling Point: 371.8 °C at 760 mmHg
• Flash Point: 178.7 °C
• Appearance: /
• Density: 1.478 g/cm³
• Vapor Pressure: 1.01E-05mmHg at 25°C
• Refractive Index: 1.532
• CAS DataBase Reference: 4-NITRO-2-(TRIFLUOROMETHYL)ACETANILIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-NITRO-2-(TRIFLUOROMETHYL)ACETANILIDE(395-68-6)
• EPA Substance Registry System: 4-NITRO-2-(TRIFLUOROMETHYL)ACETANILIDE(395-68-6)

Safety Data

• Hazard Codes: Xi
• Statements: 43
• Safety Statements: 37/39
• WGK Germany: 3
• TSCA: Yes
• HazardClass: IRRITANT
• Hazardous Substances Data: 395-68-6(Hazardous Substances Data)

Usage

Uses

Used in Organic Synthesis:
4-NITRO-2-(TRIFLUOROMETHYL)ACETANILIDE is used as a key intermediate in organic synthesis for its ability to alter the reactivity and properties of compounds, facilitating the creation of new chemical entities.
Used in Pharmaceutical Research:
In Pharmaceutical Research, 4-NITRO-2-(TRIFLUOROMETHYL)ACETANILIDE is used as a building block for the development of new pharmaceuticals, contributing to the discovery of potential drug candidates.
Used in Agrochemicals Synthesis:
4-NITRO-2-(TRIFLUOROMETHYL)ACETANILIDE is used as an intermediate in the synthesis of various agrochemicals, playing a role in the development of pesticides and other agricultural chemicals.
Used in Dyes and Pigments Production:
In the production of dyes and pigments, 4-NITRO-2-(TRIFLUOROMETHYL)ACETANILIDE is used to create a range of colorants for different applications, including textiles, plastics, and printing inks.
Safety Note:
It is crucial to handle 4-NITRO-2-(TRIFLUOROMETHYL)ACETANILIDE with care due to potential health hazards. Proper safety measures should be implemented during its use to minimize risks.

InChI:InChI=1/C9H7F3N2O3/c1-5(15)13-8-3-2-6(14(16)17)4-7(8)9(10,11)12/h2-4H,1H3,(H,13,15)

Upstream product

• 344-62-7 N-[2-(trifluoromethyl)phenyl]acetamide 
• 104-04-1 N-(4-Nitrophenyl)acetamide 
• 2926-29-6 Langlois reagent 

Downstream Products

• 121-01-7 4-nitro-2-trifluoromethyl-aniline 
• 109774-60-9 Acetyl-(4-nitro-2-trifluoromethyl-phenyl)-carbamic acid tert-butyl ester 
• 400-75-9 1-iodo-4-nitro-2-(trifluoromethyl)benzene 
• 341-58-2 2,2'-bis(trifluoromethyl)benzidine 
• 641-98-5 2,2'-bis-(trifluoromethyl)-4,4'-dinitro-1,1'-biphenyl 
• 19230-50-3 2-iodo-5-nitro-benzoic acid 

Relevant articles and documents

Preparation 2-trifluoromethyl-4-substituted aniline compounds

The invention relates to a method for preparing 2-trifluoromethyl-4-substituted phenylamine and 2-trifluoromethyl-4-substituted acetanilide. The method for preparing the2-trifluoromethyl-4-substituted phenylamine and 2-trifluoromethyl-4-substituted acetanilide comprises the following main step: in the presence of sodium trifluoromethanesulfonate and tert-butyl hydroperoxide but no metal salt catalyst and under the stirring condition, maintaining a 4-substituted phenylamine compound (concrete structure shown in a formula II is described in the specification) in a reaction medium of mixture composed of dichloromethane and water at the temperature of 0-25 DEG C for 72-120 hours, so that the 2-trifluoromethyl-4-substituted phenylamine target product is obtained. The preparation method provided by the invention has potential commercial value.

Copper-free direct C-H trifluoromethylation of acetanilides with sodium trifluoromethanesulfinate

A copper-free direct C-H ortho trifluoromethylation of electron-deficient 4-substituted acetanilides using Langlois reagent (NaSO2CF3) as the CF3 source in the presence of tert-butyl hydroperoxide (tBuOOH, TBHP) was developed.

Diaminopuridine-containing thiourea inhibitors of herpes viruses

Compounds of the formula STR1 are useful in the treatment of diseases associated with herpes viruses including human cytomegalovirus, herpes simplex viruses, Epstein-Barr virus, varicella-zoster virus, human herpesviruses-6 and -7, and Kaposi herpesvirus.