395-68-6

Basic information

• Product Name: 4-NITRO-2-(TRIFLUOROMETHYL)ACETANILIDE
• Synonyms: 2-ACETAMIDO-5-NITROBENZOTRIFLUORIDE;4'-Nitro-2'-(trifluoromethyl)acetanilide 97%;4'-Nitro-2'-(trifluoromethyl)acetanilide97%;4-NITRO-2-(TRIFLUOROMETHYL)LACETANILIDE;N1-[4-NITRO-2-(TRIFLUOROMETHYL)PHENYL]ACETAMIDE;4'-NITRO-2'-(TRIFLUOROMETHYL)ACETANILIDE;4-NITRO-2-(TRIFLUOROMETHYL)ACETANILIDE
• CAS NO: 395-68-6
• Molecular Formula: C₉H₇F₃N₂O₃
• Molecular Weight: 248.16
• Product Categories: Nitrogen Compounds;Organic Building Blocks;Protected Amines
• Mol File: 395-68-6.mol
• Article Data: 3

Chemical Properties

• Melting Point: 146-150 °C(lit.)
• Boiling Point: 371.8 °C at 760 mmHg
• Flash Point: 178.7 °C
• Appearance: /
• Density: 1.478 g/cm³
• Vapor Pressure: 1.01E-05mmHg at 25°C
• Refractive Index: 1.532
• CAS DataBase Reference: 4-NITRO-2-(TRIFLUOROMETHYL)ACETANILIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-NITRO-2-(TRIFLUOROMETHYL)ACETANILIDE(395-68-6)
• EPA Substance Registry System: 4-NITRO-2-(TRIFLUOROMETHYL)ACETANILIDE(395-68-6)

Safety Data

• Hazard Codes: Xi
• Statements: 43
• Safety Statements: 37/39
• WGK Germany: 3
• TSCA: Yes
• HazardClass: IRRITANT
• Hazardous Substances Data: 395-68-6(Hazardous Substances Data)

Usage

General Description

4-NITRO-2-(TRIFLUOROMETHYL)ACETANILIDE is a chemical compound with the molecular formula C9H7F3N2O3. It is a derivative of acetanilide and contains a nitro group and a trifluoromethyl group. This chemical is commonly used in organic synthesis and pharmaceutical research due to its significant impact on the reactivity and properties of various compounds. It is also used as an intermediate in the synthesis of various pharmaceuticals and agrochemicals. Additionally, this compound is commonly utilized in the production of dyes and pigments. However, it is important to handle this compound with care as it may pose health hazards if not handled properly.

InChI:InChI=1/C9H7F3N2O3/c1-5(15)13-8-3-2-6(14(16)17)4-7(8)9(10,11)12/h2-4H,1H3,(H,13,15)

Upstream product

• 104-04-1 N-(4-Nitrophenyl)acetamide 
• 2926-29-6 Langlois reagent 
• 344-62-7 N-[2-(trifluoromethyl)phenyl]acetamide 

Downstream Products

• 400-75-9 1-iodo-4-nitro-2-(trifluoromethyl)benzene 
• 341-58-2 2,2'-bis(trifluoromethyl)benzidine 
• 641-98-5 2,2'-bis-(trifluoromethyl)-4,4'-dinitro-1,1'-biphenyl 
• 19230-50-3 2-iodo-5-nitro-benzoic acid 
• 109774-60-9 Acetyl-(4-nitro-2-trifluoromethyl-phenyl)-carbamic acid tert-butyl ester 
• 121-01-7 4-nitro-2-trifluoromethyl-aniline 

Relevant articles and documents

Preparation 2-trifluoromethyl-4-substituted aniline compounds

The invention relates to a method for preparing 2-trifluoromethyl-4-substituted phenylamine and 2-trifluoromethyl-4-substituted acetanilide. The method for preparing the2-trifluoromethyl-4-substituted phenylamine and 2-trifluoromethyl-4-substituted acetanilide comprises the following main step: in the presence of sodium trifluoromethanesulfonate and tert-butyl hydroperoxide but no metal salt catalyst and under the stirring condition, maintaining a 4-substituted phenylamine compound (concrete structure shown in a formula II is described in the specification) in a reaction medium of mixture composed of dichloromethane and water at the temperature of 0-25 DEG C for 72-120 hours, so that the 2-trifluoromethyl-4-substituted phenylamine target product is obtained. The preparation method provided by the invention has potential commercial value.

Diaminopuridine-containing thiourea inhibitors of herpes viruses

Compounds of the formula STR1 are useful in the treatment of diseases associated with herpes viruses including human cytomegalovirus, herpes simplex viruses, Epstein-Barr virus, varicella-zoster virus, human herpesviruses-6 and -7, and Kaposi herpesvirus.