39503-61-2

Usage

Preparation

Preparation by reaction of bromine on paeonol (2-hydroxy-4-methoxyacetophenone),in methylene chloride at r.t. (quantitative yield) in acetic acid at r.t. (60%)in acetic anhydride (48%).

Upstream product

• 552-41-0 1-(2-hydroxy-4-methoxyphenyl)ethanone 
• 93483-92-2 1-(5-amino-2-hydroxy-4-methoxyphenyl)ethanone 
• 77-78-1 dimethyl sulfate 
• 89-84-9 2',4'-dihydroxy-4-acetophenone 
• 829-20-9 2',4'-dimethoxyacetophenone 
• 56923-42-3 bis-(5-acetyl-4-hydroxy-2-methoxy-phenyl)-sulfide 

Downstream Products

• 134700-76-8 Benzoic acid 2-acetyl-4-bromo-5-methoxy-phenyl ester 
• 134700-83-7 4-Methoxy-benzoic acid 2-acetyl-4-bromo-5-methoxy-phenyl ester 
• 84224-31-7 4-<(2-Acetyl-4-brom-5-methoxyphenoxy)methyl>benzonitril 
• 84223-72-3 5-Brom-2-(4-cyanphenyl)-6-methoxy-3-methyl-1-benzofuran 
• 84223-73-4 2-(4-Cyanphenyl)-6-methoxy-3-methyl-1-benzofuran 
• 1219090-52-4 1-(5-bromo-4-methoxy-2-(methoxymethoxy)phenyl)ethanone 
• 134701-12-5 4-(5-Bromo-2-hydroxy-4-methoxy-phenyl)-6-(4-methoxy-phenyl)-pyrimidin-2-ol 
• 134701-05-6 4-(5-Bromo-2-hydroxy-4-methoxy-phenyl)-6-phenyl-pyrimidin-2-ol 

Relevant academic research and scientific papers

Synthesis and anti-inflammatory activity of paeonol analogues in the murine model of complete Freund's adjuvant induced arthritis

A new series of paeonol alkyl ether analogues were synthesized and confirmed with IR,1H NMR,13C NMR and HRMS spectra. They have shown anti-inflammatory activities by scavenging mediator of free radicals and inhibiting lipid mediator

A convergent general strategy for the functionalized 2-Aryl cycloalkylfused chromans: Intramolecular hetero-diels-alder reactions of ortho-quinone methides

(Figure Presented) Five and six: 3, 4-Cyclopentyl- and cyclohexyl-fused 2-arylchromans could be readily prepared from the intramolecular hetero-Diels-Alder reactions of the corresponding ortho-quinone methide (o-QM) precursors tethered to the styrenes under mild reaction conditions. The products were obtained with good to excellent diastereoselectivity (up to > 99:1 dr; see scheme; MOM = methoxymethyl).

INHIBITORS OF HEPATITIS C VIRUS RNA-DEPENDENT RNA POLYMERASE, AND COMPOSITIONS AND TREATMENTS USING THE SAME

The present invention provides compounds of formula (4), and their pharmaceutically acceptable salts and solvates, which are useful as inhibitors of the Hepatitis C virus (HCV) polymerase enzyme and are also useful for the treatment of HCV infections in HCV-infected mammals. The present invention also provides pharmaceutical compositions comprising compounds of formula (4), their pharmaceutically acceptable salts and solvates. Furthermore, the present invention provides intermediate compounds and methods useful in the preparation of compounds of formula (4).