395063-36-2Relevant academic research and scientific papers
Synthesis of substituted-(l)-tryptophanols from an enantiomerically pure aziridine-2-methanol
Pyun, Do Kyu,Lee, Cheol Hae,Ha, Hyun-Joon,Park, Chan Sun,Chang, Jae-Won,Lee, Won Koo
, p. 4197 - 4199 (2007/10/03)
(Matrix Presented) Enantiomerically pure (l)-tryptophanol (5) was synthesized from 4(R)-iodomethyl-2-oxazolidinone (2) and indolylmagnesium bromide in three steps (52% overall yield). Using this procedure, we also prepared various tryptophanols with substituent(s) on the indole ring. Furthermore, optically active 4(R)-iodomethyl-2-oxazolidinone was readily prepared from an enantiomerically pure aziridine-2(S)-methanol in high yield.
