395066-96-3Relevant academic research and scientific papers
Synthesis of 3-fluoropyrrolidines and 4-fluoropyrrolidin-2-ones from allylic fluorides
Combettes, Lorraine E.,Schuler, Marie,Patel, Rakesh,Bonillo, Baltasar,Odell, Barbara,Thompson, Amber L.,Claridge, Tim D. W.,Gouverneur, Véronique
, p. 13126 - 13132 (2013/01/15)
Various 3-fluoropyrrolidines and 4-fluoropyrrolidin-2-ones were prepared by 5-exo-trig iodocyclisation from allylic fluorides bearing a pending nitrogen nucleophile. These bench-stable precursors were made accessible upon electrophilic fluorination of the
Palladium-catalyzed cyclization of allylsilanes with nucleophilic displacement of the silyl group
Macsari, Istvan,Szabo, Kalman J.
, p. 4097 - 4106 (2007/10/03)
Allylsilanes containing hydroxy or tosylamide groups undergo palladium(II)-catalyzed cyclization to afford derivatives of tetrahydrofuran, piperidine, and pyrrolidine. This catalytic reaction proceeds through an (η3-allyl)palladium intermediate
