395075-18-0

Upstream product

• 395075-17-9 1-O-acetyl-5-O-benzoyl-3,3-difluoro-3-deoxo-L-glyceropentofuranosid-3-ulose 
• 26661-13-2 4-N-benzoylcytosine 
• 479035-83-1 Benzoic acid (3aS,5S,6S,6aS)-6-benzyloxy-2,2-dimethyl-tetrahydro-furo[2,3-d][1,3]dioxol-5-ylmethyl ester 
• 395075-12-4 Benzoic acid (2S,3R,4S,5S)-3-benzyloxy-4-hydroxy-5-methoxy-tetrahydro-furan-2-ylmethyl ester 
• 395075-13-5 Benzoic acid (2S,3R,5S)-3-benzyloxy-5-methoxy-tetrahydro-furan-2-ylmethyl ester 
• 395075-16-8 Benzoic acid (2S,5S)-3,3-difluoro-5-methoxy-tetrahydro-furan-2-ylmethyl ester 
• 171721-11-2 5-O-benzoyl-1,2-O-isopropylidene-α-L-ribofuranose 
• 395075-14-6 Benzoic acid (2S,3R,5S)-3-hydroxy-5-methoxy-tetrahydro-furan-2-ylmethyl ester 
• 395075-15-7 Benzoic acid (2S,5S)-5-methoxy-3-oxo-tetrahydro-furan-2-ylmethyl ester 

Relevant academic research and scientific papers

l-2',3'-Didehydro-2',3'-dideoxy-3'-fluoronucleosides: synthesis, anti-HIV activity, chemical and enzymatic stability, and mechanism of resistance.

As antiviral nucleosides containing a 2',3'-unsaturated sugar moiety with 2'-fluoro substitution are endowed with increased stabilization of the glycosyl bond, it was of interest to investigate the influence of the fluorine atom at the 3'-position. Variou

Synthesis and potent anti-HIV activity of L-3′-fluoro-2′,3′-unsaturated cytidine

(Matrix Presented) L-2′,3′-Didehydro-2′,3′-dideoxy-3′-fluorocytidine (L-3′-Fd4C), a novel potent anti-HIV agent (EC50 0.03 μM in PBM cells), has been synthesized from L-xylose in 14 steps.