395098-94-9

Upstream product

• 71432-55-8 2-tert-butyl-1,3-diisopropylisourea 
• 6482-98-0 2-hydroxy-3-(4-hydroxyphenyl)propanoic acid 
• 863482-21-7 t-butyl 3-(4-benzyloxyphenyl)-2,3-epoxypropanoate 

Downstream Products

• 395098-96-1 (+/-)-tert-butyl 2-O-(4-tert-butyldimethylsilylcoumaroyl)-3-(4-tert-butyldimethylsilyloxyphenyl)lactate 
• 395098-97-2 (+/-)-tert-butyl 2-O-(4-coumaroyl)-3-(4-hydroxyphenyl)lactate 
• 395098-95-0 (+/-)-tert-butyl 3-(4-tert-butyldimethylsilyloxyphenyl)lactate 

Relevant academic research and scientific papers

PROCESSES FOR MAKING PIOGLITAZONE AND COMPOUNDS OF THE PROCESSES

Pioglitazone can be made via a Darzens Condensation reaction in an industrially useful process.

Synthesis of 2-O-(4-coumaroyl)-3-(4-hydroxyphenyl)lactic acid, an important intermediate of rosmarinic acid biosynthesis

A simple method to synthesize (±)-2-O -(4-coumaroyl)-3-(4-hydroxyphenyl)lactic acid (1), a key intermediate in rosmarinic acid biosynthesis in higher plant cells, was established by condensation of protected 4-coumaric acid and (±)-3-(4-hydroxyphenyl)lact