3951-44-8 Usage
Uses
Used in Pharmaceutical Industry:
4H-1-Benzopyran-4-one, 5,6,7-trihydroxy-2-(2-hydroxyphenyl)is used as a research compound for studying its potential effects on CYP 450 monooxygenases. These enzymes are crucial in the metabolism of organic molecules and drugs, and understanding how 4H-1-Benzopyran-4-one, 5,6,7-trihydroxy-2-(2-hydroxyphenyl)- interacts with them can lead to advancements in drug development and personalized medicine.
Used in Chemical Research:
As an impurity of flavone, 4H-1-Benzopyran-4-one, 5,6,7-trihydroxy-2-(2-hydroxyphenyl)is used in chemical research to investigate its role in the overall properties and functions of flavone compounds. This can help in understanding the complex interactions between different components in natural products and their potential applications in various industries.
Used in Quality Control and Analysis:
The presence of 5,6,7,2′-Tetrahydroxyflavone as an impurity in flavone can be relevant in quality control and analysis of flavone-containing products. By studying its properties and effects, it is possible to establish standards and methods for detecting and quantifying this impurity, ensuring the purity and safety of flavone-based products in the market.
Check Digit Verification of cas no
The CAS Registry Mumber 3951-44-8 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 3,9,5 and 1 respectively; the second part has 2 digits, 4 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 3951-44:
(6*3)+(5*9)+(4*5)+(3*1)+(2*4)+(1*4)=98
98 % 10 = 8
So 3951-44-8 is a valid CAS Registry Number.
3951-44-8Relevant academic research and scientific papers
Importance of the B ring and its substitution on the α-glucosidase inhibitory activity of baicalein, 5,6,7-trihydroxyflavone
Gao, Hong,Kawabata, Jun
, p. 1858 - 1864 (2007/10/03)
Hydroxychroniones and B-ring-substituted 5,6,7-trihydroxyflavones were prepared to evaluate the contribution of the B ring of baicalein (5,6,7-trihydroxyflavone, 1) to its potent α-glucosidase inhibitory activity. Hydroxychromones, which lack 6-hydroxyl substitution, did not show any inhibitory activity, while 5,6,7-trihydroxy-2-methylchromone (5) showed high activity. Among the tested B-ring-substituted 5,6,7-trihydroxyflavones, the 4′-hydroxy-, 3′,4′-dihydroxy-, and 3′,4′,5′- trihydroxy-substituted derivatives were found to give more activity than that of 1. The methoxy-substituted derivatives, however, showed less activity than 1. The results suggest that the B ring of 1 was not essential, although advantageous to the activity; hydroxyl substitution on the B ring of 5,6,7-trihydroxyflavones was favorable to the activity, whereas methoxyl substitution was unfavorable; at least 4′-hydrosyl substitution of 5,6,7-trihydroxyflavones was required for enhanced activity, in which the number of hydroxyl groups did not take part.
