3951-89-1

Basic information

• Product Name: 7-BROMO-1,2,3,4-TETRAHYDRO-BENZO[B]AZEPIN-5-ONE
• Synonyms: 7-BROMO-1,2,3,4-TETRAHYDRO-BENZO[B]AZEPIN-5-ONE;7-Bromo-1,2,3,4-tetrahydro-5H-1-benzazepin-5-one;7-bromo-3,4-dihydro-1H-benzo[b]azepin-5(2H)-one
• CAS NO: 3951-89-1
• Molecular Formula: C₁₀H₁₀BrNO
• Molecular Weight: 240.1
• Mol File: 3951-89-1.mol
• Article Data: 3

Chemical Properties

• Melting Point: 107 °C
• Boiling Point: 370.2±41.0 °C(Predicted)
• Appearance: /
• Density: 1.475±0.06 g/cm3(Predicted)
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 2.17±0.20(Predicted)
• CAS DataBase Reference: 7-BROMO-1,2,3,4-TETRAHYDRO-BENZO[B]AZEPIN-5-ONE(CAS DataBase Reference)
• NIST Chemistry Reference: 7-BROMO-1,2,3,4-TETRAHYDRO-BENZO[B]AZEPIN-5-ONE(3951-89-1)
• EPA Substance Registry System: 7-BROMO-1,2,3,4-TETRAHYDRO-BENZO[B]AZEPIN-5-ONE(3951-89-1)

Safety Data

• Hazard Codes: T
• Statements: 25
• Safety Statements: 45
• Hazardous Substances Data: 3951-89-1(Hazardous Substances Data)

Usage

General Description

7-Bromo-1,2,3,4-tetrahydro-benzo[b]azepin-5-one, also known as UNII-9UB351D0E7, is a chemical compound with a molecular formula of C12H12BrNO. As its name suggests, it has a bromine atom attached to its structure. This chemical belongs to the class of organic compounds known as benzazepines, which are organic compounds containing a benzene ring fused to an azepine ring(a seven-membered heterocyclic compound with one nitrogen atom replacing a carbon atom). The detailed properties, such as its density, melting point, boiling point, and solubility in various solvents, largely depend on its specific chemical structure and the presence of the bromine atom, but are not immediately available in available resources. Its applications and potential uses are not widely documented in current scientific literature.

Upstream product

• 872624-49-2 (+/-)-1-isopropyl-4-methyl-7-bromo-5-oxo-2,3,4,5-tetrahydrobenzo[b]azepine-1,4-dicarboxylate 
• 52727-57-8 5-bromo-2-aminobenzoic acid methyl ester 
• 223526-84-9 methyl 5-bromo-2-{[(4-methylphenyl)sulfonyl]amino}benzoate 

Downstream Products

• 313724-26-4 7-bromo-1-(t-butoxycarbonyl)-1,2,3,4-tetrahydro-1-benzazepin-5-one 
• 313740-83-9 7-{4-[2-(butoxy)ethoxy]phenyl}-N-(4-{[methyl(tetrahydro-2H-pyran-4-yl)amino]methyl}phenyl)-1-propyl-2,3-dihydro-1H-1-benzazepine-4-carboxamide 
• 313738-91-9 7-[4-(2-butoxyethoxy)phenyl]-1-propyl-2,3,4,5-tetrahydro-1H-1-benzazepine-5-one 
• 313738-96-4 7-{4-[2-(butoxy)ethoxy]phenyl}-1-propyl-2,3-dihydro-1H-1-benzazepine-4-carboxylic acid 
• 739355-72-7 7-{4-[2-(butoxy)ethoxy]phenyl}-1-cyclobutylmethyl-N-(4-{[methyl(tetrahydro-2H-pyran-4-yl)amino]methyl}phenyl)-2,3-dihydro-1H-1-benzazepine-4-carboxamide 
• 719297-15-1 methyl 7-{4-[2-(butoxy)ethoxy]phenyl}-1-[(1-methyl-1H-imidazol-2-yl)methyl]-2,3-dihydro-1H-1-benzazepine-4-carboxylate 
• 719297-16-2 methyl 7-{4-[2-(butoxy)ethoxy]phenyl}-1-[(1-methyl-1H-pyrazol-4-yl)methyl]-2,3-dihydro-1H-1-benzazepine-4-carboxylate 
• 313753-40-1 methyl 7-{4-[2-(butoxy)ethoxy]phenyl}-1-[(1-methyl-1H-pyrazol-5-yl)methyl]-2,3-dihydro-1H-1-benzazepine-4-carboxylate 
• 313752-00-0 7-{4-[2-(butoxy)ethoxy]phenyl}-1-[(1-methyl-1H-pyrazol-5-yl)methyl]-2,3-dihydro-1H-1-benzazepine-4-carboxylic acid 
• 313751-95-0 7-{4-[2-(butoxy)ethoxy]phenyl}-1-[(1-methyl-1H-pyrazol-4-yl)methyl]-2,3-dihydro-1H-1-benzazepine-4-carboxylic acid 

Relevant articles and documents

COMPOUNDS AND METHODS FOR TREATING DYSLIPIDEMIA

Compounds of Formula (I): wherein n, m, p, q, Y, R1 R2, R3a, R3b, R4, R5, and R6 are as defined herein and their pharmaceutical compositions and methods of use are disclosed.

BENZAZEPINE DERIVATIVES, PROCESS FOR THE PREPARATION OF THE SAME AND USES THEREOF

Compounds of the general formula (I): or salts thereof, which exhibit CCR5 antagonism and exert preventive and therapeutic effects against HIV infections: wherein R1 is a 5- to 6-membered aromatic ring which bears a substituent represented by the general formula: R-Z1-X-Z2- (wherein R1 is hydrogen or optionally substituted hydrocarbyl; X is optionally substituted alkylene; and Z1 and Z2 are each a heteroatom) and may be further substituted, with R being optionally bonded to the aromatic ring to form another ring; Y is optionally substituted imino; and R2 and R3 are each optionally substituted aliphatic hydrocarbyl or an optionally substituted hetero-alicyclic group.