395100-93-3

Usage

Molecular structure

Consists of an indazole ring with a carboxylic acid group, a fluorophenyl group, and a hydrazide group linked to the indazole ring through a 1,1-dimethylethoxy carbonyl group.

Indazole ring

A five-membered aromatic ring with a nitrogen atom at position 1.

Carboxylic acid group

A functional group consisting of a carbonyl group (C=O) and a hydroxyl group (OH) attached to the same carbon atom.

Fluorophenyl group

A phenyl group (a six-membered aromatic ring) with a fluorine atom attached to the carbon atoms.

Hydrazide group

A functional group consisting of a nitrogen atom bonded to two hydrazine groups (-NH-NH2).

1,1-Dimethylethoxy carbonyl group

A carbonyl group (C=O) with a 1,1-dimethylethoxy group (CH3-O-CH(CH3)-) attached to the carbon atom.

Potential pharmaceutical applications

May be used in research or in the development of new drugs or biologically active compounds due to its unique structure and properties.

Further studies needed

Investigations are required to fully understand the potential uses and effects of this chemical.

Upstream product

• 395100-00-2 1-acetyl-3-(4-fluorophenyl)-1H-indazole-5-carbonyl chloride 

Downstream Products

• 395100-95-5 N-amino[3-(4-fluorophenyl)(1H-indazol-5-yl)]carboxamide 

Relevant academic research and scientific papers

Indazole compounds, compositions thereof and methods of treatment therewith

This invention is generally directed to the use of Indazole Compounds for treating or preventing diseases associated with protein kinases, including tyrosine kinases, such as proliferative diseases, inflammatory diseases, abnormal angiogenesis and diseases related thereto, atherosclerosis, macular degeneration, diabetes, obesity, pain and others. The methods comprise the administration to a patient in need thereof of an effective amount of an indazole compound that inhibits, modulates or regulates tyrosine kinase signal transduction. Novel indazole compounds or pharmaceutically acceptable salt thereof are presented herein.

Methods for treating an inflammatory condition or inhibiting JNK

This invention is generally directed to Indazole Derivatives having the following structure: 1 or pharmaceutically acceptable salt thereof, wherein R1, R2 and A are as defined herein. Such compounds have utility in the treatment of a wide range of diseases and disorders that are responsive to JNK inhibition, such as an inflammatory disease or disorder. Thus, methods of treating such diseases and disorders are also disclosed, as are pharmaceutical compositions containing one or more compounds of the above compounds.

Indazole derivatives as JNK inhibitors and compositions and methods related thereto

Compounds having activity as selective inhibitors of JNK are disclosed. The compounds of this invention are indazole derivatives having the following structure: wherein R1, R2 and A are as defined herein. Such compounds have utility in the treatment of a wide range of conditions that are responsive to JNK inhibition. Thus, methods of treating such conditions are also disclosed, as are pharmaceutical compositions containing one or more compounds of the above compounds.