39512-49-7

Usage

Uses

Used in Pharmaceutical Research:
4-(4-Chlorophenyl)piperidin-4-ol is used as a potential fluorescent sigma receptor probe for [application reason] its ability to interact with sigma receptors, which are involved in various cellular processes and have been implicated in several diseases. 4-(4-Chlorophenyl)piperidin-4-ol can be utilized in the development of new drugs targeting these receptors, potentially leading to novel therapeutic approaches for conditions such as neurodegenerative diseases, pain management, and psychiatric disorders.
Used in Chemical Synthesis:
In the field of chemical synthesis, 4-(4-Chlorophenyl)piperidin-4-ol can be used as a building block or intermediate for the synthesis of more complex molecules with specific biological activities. Its unique structure allows for further functionalization and modification, making it a valuable starting material for the development of new pharmaceuticals, agrochemicals, or other specialty chemicals.
Used in Analytical Chemistry:
4-(4-Chlorophenyl)piperidin-4-ol can also be employed as a reference compound or standard in analytical chemistry. Its distinct spectral properties and reactivity can be used to calibrate instruments, validate analytical methods, or establish reference values for the identification and quantification of similar compounds in various samples.

InChI:InChI=1/C11H14ClNO/c12-10-3-1-9(2-4-10)11(14)5-7-13-8-6-11/h1-4,13-14H,5-8H2/p+1

Upstream product

• 91335-13-6 4-Brom-4-(4-chlor-phenyl)-piperidin 
• 235109-63-4 4-(4-chloro-phenyl)-4-hydroxy-piperidine-1-carboxylic acid tert-butyl ester 
• 873-77-8 (4-chlorphenyl)magnesium bromide 
• 79099-07-3 N-tert-butyloxycarbonylpiperidin-4-one 
• 26905-02-2 4-(4-chlorophenyl)piperidine 
• 106-39-8 bromochlorobenzene 
• 4783-65-7 N-benzyl-2-piperidinone 
• 56108-25-9 N-benzyl-4-(4-chlorophenyl)-4-hydroxypiperidin 

Downstream Products

• 52-86-8 haloperidol 
• 31293-71-7 VUF 5666 
• 26438-75-5 1-[3-(2-chloro-phenothiazin-10-yl)-propyl]-4-(4-chloro-phenyl)-piperidin-4-ol 
• 90126-08-2 4-(4-Chloro-phenyl)-1-(2-pyridin-2-yl-ethyl)-piperidin-4-ol; compound with (Z)-but-2-enedioic acid 
• 91126-04-4 4-(p-Chlorphenyl)-1-cyanaminomethylen-4-hydroxypiperidin 
• 117992-75-3 2-{2-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-ethyl}-isoindole-1,3-dione 
• 110319-90-9 2-<<4-(4-chlorophenyl)-4-hydroxy-1-piperidinyl>methyl>-5-(4-fluorophenyl)pyrrole 
• 80775-82-2 4-<4-(4-chlorophenyl)-4-hydroxy-1-piperidinyl>-4-(4-methoxyphenyl)-1-phenyl-1-butanone 
• 129355-80-2 4-<4-(p-chlorophenyl)-4-hydroxypiperidino>-4'-(N-methylacetamido)butyrophenone 
• 43141-21-5 N-propargyl-4-(4'-chlorophenyl)-4-piperidinol 
• 140439-01-6 6-{6-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-hexyloxy}-2-phenyl-chromen-4-one 
• 1145-92-2 (1SR,2SR)-phenyl(2-phenylcyclopropyl)ketone 
• 42509-32-0 4-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-1,3-diphenyl-butan-1-one 
• 41819-42-5 1,4-diphenyl-4-<4-(4-chlorophenyl)-4-hydroxy-1-piperidinyl->1-butanone 

Relevant academic research and scientific papers

Preparation method of flupiperidinol

The invention belongs to the technical field of medicine preparation, and particularly relates to a preparation method of flupiperidinol. The preparation method of the fluoropiperidinol, provided by the invention, comprises the following steps of providing 4-(4-chlorphenyl)-4-piperidinol of which the purity is 99% or above, providing 4-chloro-1-(4-fluorophenyl)butan-1-one of which the purity is more than 99%, mixing the 4-(4-chlorphenyl)-4-piperidinol, 4-chloro-1-(4-fluorophenyl)butan-1-one, an alkaline substance and a catalyst, and carrying out a first substitution reaction to obtain a crudeproduct, and mixing the crude product with an organic solvent, and sequentially carrying out reflux and crystallization to obtain the flupiperidinol. The flupiperidinol prepared according to the preparation method provided by the invention has relatively high yield and purity.

Structure-Kinetic Profiling of Haloperidol Analogues at the Human Dopamine D2 Receptor

Haloperidol is a typical antipsychotic drug (APD) associated with an increased risk of extrapyramidal side effects (EPSs) and hyperprolactinemia relative to atypical APDs such as clozapine. Both drugs are dopamine D2 receptor (D2R) antagonists, with contrasting kinetic profiles. Haloperidol displays fast association/slow dissociation at the D2R, whereas clozapine exhibits relatively slow association/fast dissociation. Recently, we have provided evidence that slow dissociation from the D2R predicts hyperprolactinemia, whereas fast association predicts EPS. Unfortunately, clozapine can cause severe side effects independent of its D2R action. Our results suggest an optimal kinetic profile for D2R antagonist APDs that avoids EPS. To begin exploring this hypothesis, we conducted a structure-kinetic relationship study of haloperidol and revealed that subtle structural modifications dramatically change binding kinetic rate constants, affording compounds with a clozapine-like kinetic profile. Thus, optimization of these kinetic parameters may allow development of novel APDs based on the haloperidol scaffold with improved side-effect profiles.

Remote C(sp3)-H Oxygenation of Protonated Aliphatic Amines with Potassium Persulfate

This letter describes the development of a method for selective remote C(sp3)-H oxygenation of protonated aliphatic amines using aqueous potassium persulfate. Protonation serves to deactivate the proximal C(sp3)-H bonds of the amine substrates and also renders the amines soluble in the aqueous medium. These reactions proceed under relatively mild conditions (within 2 h at 80 °C with amine as limiting reagent) and do not require a transition metal catalyst. This method is applicable to a variety of types of C(sp3)-H bonds, including 3°, 2°, and benzylic C-H sites in primary, secondary, and tertiary amine substrates.

METALLO-BETA-LACTAMASE INHIBITORS

The present invention relates to compounds of formula (I) that are metallo-β-lactamase inhibitors, the synthesis of such compounds, and the use of such compounds for use with β-lactam antibiotics for overcoming resistance.

METALLO-BETA-LACTAMASE INHIBITORS

The present invention relates to compounds of formula (I) that are metallo-β-lactamase inhibitors, the synthesis of such compounds, and the use of such compounds for use with β-lactam antibiotics for overcoming resistance.

DRUG COMBINATIONS CONTAINING PDE4 INHIBITORS AND NSAIDS

The present invention relates to new drug combinations which contain in addition to one or more PDE4-inhibitors at least one NSAID (=non-steroidal anti-inflammatory drug) (2), processes for preparing them and their use in treating in particular respiratory complaints such as for example COPD, chronic sinusitis and asthma. The invention particularly relates to those drug combinations which contain, in addition to one or more, preferably one PDE4 inhibitor of general formula 1 wherein X is SO or SO2, but preferably SO, and wherein R1, R2, R3 and R4 have the meanings given in claim 1, at least one NSAID (2), the preparation thereof and the use thereof for the treatment of respiratory complaints.

Synthesis and SAR study of diphenylbutylpiperidines as cell autophagy inducers

A novel series of diphenylbutylpiperidines as autophagy inducers was described and extensive SAR studies resulted in derivatives (15d-e, 15i-j) with 10-fold greater activity than the lead compounds 1 and 2. Meanwhile, a new synthetic route to diphenylbutyl bromide (6) from bromobenzene and γ-butyrolactone was also reported here.

DIPHENYLBUTYPIPERIDINE AUTOPHAGY INDUCERS

Autophagy inducing compounds, methods of their preparation and use, and kits containg said compounds are disclosed herein.