39516-07-9Relevant academic research and scientific papers
Enantioselective oxidation of secondary alcohols by Candida parapsilosis ATCC 7330
Sivakumari, Thakkellapati,Preetha, Radhakrishnan,Chadha, Anju
, p. 2257 - 2262 (2014/01/06)
Optically pure allylic alcohols and 4-phenylbutan-2-ols were prepared by oxidative kinetic resolution using whole cells of Candida parapsilosis ATCC 7330. Only the 'S' enantiomer is selectively oxidized to the corresponding keto compound (yield, 37-46%) leaving the 'R' alcohol (yield, 37-52% and ee 46 to >99%). The biocatalytic method is carried out under mild conditions at 20°C, pH 6.5 in phosphate buffer.
