39560-71-9Relevant academic research and scientific papers
Structure activity relationships for 5 substituted 2 nitrofuryl pyrimidines
Seydel,Albrecht
, p. 378 - 386 (2007/10/05)
22 Derivatives of 2 (5 nitro 2 furyl) 5 (2 amino ethoxy) pyrimidine were synthesized, which have an alkyl group or substituted alkyl group and an acyl moiety at the amino group (structure 1). The minimal inhibitory concentrations (MIC) against E. coli and the R(m) values were determined. Significant correlations between log (MIC) and R(m) values are obtained if the derivatives are divided into two groups which differ in the dependence of the R(m) value on the composition of the solvent system used for chromatography. In relation to the structure, this yields two series in which the modified groups a) are unbranched alkyl groups or b) contain ester or ether functions or a branched alkyl group. The same separation is obtained if the R(m paraffin) values are plotted as a function of the R(m polyamide) values. In both series, the biological activity decreases with increasing lipophilicity of the compounds, among equivalent lipophilic compounds; however, those according to a) are more active.
