39567-74-3Relevant academic research and scientific papers
Rhodium(III)-Catalyzed Imidoyl C-H Activation for Annulations to Azolopyrimidines
Halskov, Kim S?holm,Witten, Michael R.,Hoang, Gia L.,Mercado, Brandon Q.,Ellman, Jonathan A.
, p. 2464 - 2467 (2018)
Azolopyrimidines are efficiently prepared by direct imidoyl C-H bond activation. Annulations of N-azolo imines with sulfoxonium ylides and diazoketones under redox-neutral conditions and alkynes under oxidizing conditions provide products with various arrangements of nitrogen atoms and carbon substituents. We have also probed the mechanism of this first example of Rh(III)-catalyzed direct imidoyl C-H activation by structural characterization of a catalytically competent rhodacycle obtained after C-H activation and by kinetic isotope effects.
