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39577-43-0

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  • High quality 1-(3-Chlorophenyl)-4-(3-Chloropropyl)Piperazine Hydrochloride supplier in China

    Cas No: 39577-43-0

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39577-43-0 Usage

Chemical Properties

WHITE TO BEIGE POWDER

Uses

1-(3-Chlorophenyl)-4-(3-chloropropyl)piperazine is used in method of continuous flow process for preparation of Trazodone.Also, used in preparation of of Benzoaza-Alkylaryl Piperazine derivatives for treatment of mental diseases.

Check Digit Verification of cas no

The CAS Registry Mumber 39577-43-0 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 3,9,5,7 and 7 respectively; the second part has 2 digits, 4 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 39577-43:
(7*3)+(6*9)+(5*5)+(4*7)+(3*7)+(2*4)+(1*3)=160
160 % 10 = 0
So 39577-43-0 is a valid CAS Registry Number.
InChI:InChI=1/C13H18Cl2N2/c14-5-2-6-16-7-9-17(10-8-16)13-4-1-3-12(15)11-13/h1,3-4,11H,2,5-10H2

39577-43-0SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 20, 2017

Revision Date: Aug 20, 2017

1.Identification

1.1 GHS Product identifier

Product name 1-(3-Chlorophenyl)-4-(3-chloropropyl)piperazine

1.2 Other means of identification

Product number -
Other names -

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:39577-43-0 SDS

39577-43-0Relevant articles and documents

Synthesis and pharmacological screening of some N-(4-substituted-piperazin-1-ylalkyl)-3,4-pyrroledicarboximides

Malinka, Wieslaw,Sieklucka-Dziuba, Maria,Rajtar, Grazyna,Rubaj, Andrzej,Kleinrok, Zdzislaw

, p. 390 - 401 (1999)

As an extension of our previous work we describe the synthesis and pharmacological investigation of a new series of derivatives of pyrrole-3,4-dicarboximide possessing the 4-substituted-piperazin-1-ylalkyl group linked to the imide nitrogen. The products were evaluated for acute toxicity, and effectiveness in a series of CNS and arterial blood pressure tests. The preliminary pharmacological screening was determined in animal models. Several compounds demonstrated moderate to high analgesic activity in the 'writhing syndrome' test (5f-1/640 LD50). Some of the structure-activity relationships are also discussed.

CONTINUOUS PROCESS FOR THE PREPARATION OF TRAZODONE

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Page/Page column 23-25, (2019/08/29)

The present invention relates to an improved process for the preparation of trazodone. In particular, the present invention relates to a continuous process for the preparation of trazodone. More in particular, the present invention relates to a new method for the preparation of trazodone, said method comprising at least one step consisting of a continuous process performed in a flow reactor.

Synthesis, characterization, and anticancer studies of S and N alkyl piperazine-substituted positional isomers of 1,2,4-triazole derivatives

Murty,Ram, Kesur R.,Rao, B. Ramalingeswara,Rao, Rayudu Venkateswara,Katiki, Mohana Rao,Rao, Janapala Venkateswara,Pamanji,Velatooru

, p. 1661 - 1671 (2014/05/06)

A series of 3-[3-[4-(substituted)-1-cyclicamine] propyl]thio-5- substituted[1,2,4]triazoles (8a-m) and 2-[3-[4-(substituted)-1-cyclicamine] propyl]-5-(substituted)-2,4-dihydro-3H[1,2,4]triazole-3-thiones (9a-h) were synthesized with good yields starting from corresponding carboxylic acids using two different methods. The cytotoxicity studies of these derivatives were studied against five different human cancer cell lines. Six compounds had shown good anticancer activity. The triazole derivatives, 9d, 8j, and 8i were most potent particularly against U937 and HL-60 cells. The cytotoxic potency of the compounds varied between the cell lines suggesting that a structural property of these compounds as possible determinant of their biological activity. Springer Science+Business Media 2013.

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