396090-71-4

Upstream product

• 396090-74-7 C₂₅H₂₃NO₆ 
• 23735-43-5 (S)-1-O-tosyl-2,3-O-isopropylideneglycerol 
• 23788-74-1 (R)-2,2-dimethyl-1,3-dioxolane-4-ylmethyl p-toluenesulfonate 

Downstream Products

• 396090-78-1 3-(1-methylindol-3-yl)-4-{3-[((R)-2-hydroxy-2-hydroxymethyl)ethyloxy]phenyl}-1H-pyrrole-2,5-dione 
• 396090-82-7 30³ 

Relevant academic research and scientific papers

Discovery of potent and bioavailable GSK-3β inhibitors

Here we report on the discovery of a series of maleimides which have high potency and good selectivity for GSK-3β. The incorporation of polar groups afforded compounds with good bioavailability. The most potent compound 34 has an IC50 of 0.6 nM for GSK-3β, over 100-fold selectivity against a panel of other kinases, and shows efficacy in rat osteoporosis models. The X-ray structure of GSK-3β protein with 34 bound revealed the binding mode of the template and provided insights for future optimization opportunities.