396123-73-2

Upstream product

• 396123-72-1 6-azido-9-[2',3'-O-(1R)-benzylidene-β-D-ribofuranosyl]purine 
• 396123-64-1 bis(O-benzylphosphonomethyl)phosphinic acid benzyl ester 
• 1125-88-8 benzaldehyde dimethyl acetal 
• 58-63-9 Inosine 
• 165271-66-9 tetrabenzyl <<(benzyloxy)phosphoryl>bis(methylene)>bis(phosphonate) 
• 100-51-6 benzyl alcohol 
• 384375-15-9 methaneselenophosphonic acid O,O'-dibenzyl ester 
• 396123-70-9 6-chloro-9-[2',3'-O-(1R)-benzylidene-β-D-ribofuranosyl]purine 
• 396123-63-0 bis(O,O'-dibenzyl selenophosphonomethyl)benzyl phosphinite 
• 396123-62-9 bis(O,O'-dibenzyl selenophosphonomethyl) N,N-dimethylaminophosphine 
• 396123-66-3 bis(O-benzyl-O'-methyl phosphonomethyl)phosphinic acid benzyl ester 
• 396123-68-5 5'-O-acetyl-2',3'-O-(1R)-benzylideneinosine 
• 396123-69-6 6-chloro-9-[5'-O-acetyl-2',3'-O-(1R)-benzylidene-β-D-ribofuranosyl]purine 
• 396123-67-4 2',3'-O-(1R)-benzylideneinosine 

Relevant academic research and scientific papers

Synthesis of enzymatically and chemically non-hydrolyzable analogues of dinucleoside triphosphates Ap3A and Gp3G

Dinucleoside polyphosphates are ubiquitous compounds tightly involved in the regulation of a number of key biological processes. Hydrolysis-resistant analogues of Ap3A and Gp3G, two important members of that family of nucleotides, have been synthesized. P1,P2.P2,P3-Bis-methylene diadenosine and diguanosine triphosphates were prepared from O,O-dialkyl methaneselenophosphonates using an original methodology. Whereas the 2-fold addition of the methanephosphonate anion to the activated phosphorus species cannot be performed, multiple condensation of lithiated methaneselenophosphonate with electrophilic trivalent phosphorus compounds is revealed to be very effective. A one-pot condensation/esterification/oxidation sequence involving O,O-dialkyl methaneselenophosphonates provides a highly efficient route to the PCH2PCH2P backbone. This new development in selenophosphonate chemistry offers a great potential for further regioselective functionalization of polyphosphate mimics.