39627-76-4Relevant academic research and scientific papers
Conformations and rotational barriers of (Z)-1,2-α-naphthostilbene crown ethers and their alkali metal complexes
Merz, Andreas,Gromann, Lutz,Karl, Andreas,Burgemeister,Kastner
, p. 1635 - 1640 (1996)
The synthesis of 2,3-didehydro[15]crown-5 and -[18]crown-6 derivatives 4a, b with vicinal α-naphthyl groups at the double bonds starting from α-naphthoin (3) is described. The barriers to rotation of the naphthyl groups were probed by MM2 and by dynamic 1H-NMR spectroscopy. An achiral syn and a chiral anti conformation were experimentally observed at -90°C for the free ligands and at -40°C for the complexes. The experimental ΔG? and the calculated ΔH? values are in fair agreement. The barriers are substantially higher in the alkali metal complexes than in the free ligands. In the presence of racemic and potassium S-(+)-mandelate nonequilibrating ion pairs with 4b were observed by low-temperature 1H-NMR spectroscopy for the anti conformation. VCH Verlagsgesellschaft mbH, 1996.
Development of Imidazoline-2-one Derivatives as Potential Antifungal and Anthelminthic Agents: in silico and in vitro Evaluation
Chilamakuru, Naresh Babu,Mallela, Vijaya Jyothi,Peraman, Ramalingam,Shaik, Shakir Basha,Simham, Venu,Singirisetty, Triveni
, p. 423 - 433 (2021/11/24)
Based on appropriate values of synthetic accessibility concerning from ADMET properties and docking scores by docking against proteins 3OZU and 1OJ0, a series of 4,5-diphenyl-1H-imidazol-2-ones (I1?15) were synthesized. The key intermediate, 2-hydroxy-1,2-disubstitutedethanones (E1?15) were prepared by benzoin condensation using 2:1 ratio of aromatic aldehydes and thiamine in the presence of alkali. Further, these cyclized ethanones (E1?15) were treated with urea to yield 4,5-diphenyl-1H-imidazol-2-one derivatives (I1?15) and were characterized by IR,1H NMR, Mass spectra, and CHNO analysis. The synthesized compounds were screened for their anthelmintic potential on Pheretima Posthuma along with standard albendazole, and antifungal activity (minimum inhibitory concentration method) on Candida albicans and Aspergillus niger along with standard miconazole. The results revealed that among all the tested compounds I3, I4, and I7 show considerable synthetic accessibility, docking scores, anthelminthic, and antifungal activity.
Synthesis and evaluation of naphthoic acid derivatives as fluorescent probes to screen advanced glycation end-products breakers
Séro, Luc,Calard, Fran?ois,Sanguinet, Lionel,Levillain, Eric,Richomme, Pascal,Séraphin, Denis,Derbré, Séverine
supporting information, p. 6716 - 6720 (2013/01/14)
Advanced glycation end-products, namely AGEs, are involved in the pathogenesis of numerous diseases. If AGEs inhibitors are well-known, only few products are described as compounds able to destroy those deleterious products. In this work, we describe naphthoic acid derivatives, particularly 1-(naphthalen-1-yl)propane-1,2-dione 9, allowing the simple and rapid detection of AGEs breakers using a 96-well microplate fluorescence assay. Since the inaugurate publication about AGEs breakers whose activity was demonstrated using HPLC analysis, this work proposes the first assay suitable for automated and high throughput screening of AGEs breakers.
Methylene-bridged bis(benzimidazolium) salt as a highly efficient catalyst for the benzoin reaction in aqueous media
Iwamoto, Ken-Ichi,Kimura, Hitomi,Oike, Masaaki,Sato, Masayuki
experimental part, p. 912 - 915 (2008/10/09)
Benzoin reactions are catalyzed effectively by a methylene-bridged bis(benzimidazolium) salt to yield α-hydroxy ketones, and the reactions proceed in water as the aqueous medium under mild conditions. The Royal Society of Chemistry.
