39635-23-9

Upstream product

• 1000002-30-1 2-methyl-5-[4-methyl-3-(2-trimethylsilanyl-ethoxymethoxy)-phenyl]-[1,3,4]oxadiazole 
• 33414-48-1 3-hydroxy-p-toluic acid ethyl ester 
• 3556-86-3 methyl 4-methyl-3-hydroxybenzoate 

Downstream Products

• 1000002-65-2 3-hydroxy-4-methyl-benzoic acid N'-[2-(4-chloro-phenyl)-acetyl]-hydrazide 
• 1000002-70-9 3-hydroxy-4-methyl-benzoic acid N'-(4-chloro-benzoyl)-hydrazide 
• 1000002-35-6 2-methyl-5-(5-methyl-[1,3,4]oxadiazol-2-yl)-phenol 

Relevant academic research and scientific papers

Antileishmanial activity screening of 5-nitro-2-heterocyclic benzylidene hydrazides

A series of 53 nitro derivatives rationally designed were obtained by parallel synthesis and screened against Leishmania donovani. Six compounds exhibited IC50 values lower than standard drugs. Brief SAR analysis revealed that substitution is important to the activity. Nitrothiophene analogues were more potent than the nitrofuran ones. This was attributed to the ability of sulfur atoms in accommodating electrons from nitro group, which facilitate its reduction and therefore the formation of free radicals lethal to parasites.

Substituted Thieno[3,2-C]Pyridine-7-Carboxylic Acid Derivatives

There are provided compounds of the formula wherein R1, R2, R3, X, Y, Q, Ring A and Ring B are as described. The compounds exhibit activity as anticancer agents.

Substituted thieno[3,2-C]pyridine carboxylic acid derivatives

There are provided compounds of the formula wherein R1, R2, R3, X, ring A and ring B are as described. The compounds exhibit anticancer properties.