39636-32-3

Upstream product

• 77-60-1 tigogenin 
• 98-59-9 p-toluenesulfonyl chloride 
• 512-04-9 diosgenin 
• 77-60-1 3-epismilagenin 
• 512-07-2 (25R)-5β-spirostan-3-one 
• 126-19-2 sarsasapogenin 

Downstream Products

• 5012-14-6 (25R)-5α-Spirostan 
• 885453-86-1 gitotenin 2α-O-benzyl-3β-O-(2,3,4,6-tetra-O-benzoyl-β-D-galactopyranoside) 
• 885453-91-8 gitogenin 2α-O-benzyl-3β-O-(2,3,4,6-tetra-O-benzoyl-β-D-glucopyranoside) 
• 885453-88-3 gitotenin 2α-O-benzyl-3β-O-(3,6-di-O-benzoyl-β-D-galactopyranoside) 
• 885453-94-1 gitogenin 2α-O-benzyl-3β-O-(3,6-di-O-benzoyl-β-D-glucopyranoside) 
• 885453-87-2 gitotenin 2α-O-benzyl-3β-O-(β-D-galactopyranoside) 
• 885453-93-0 C₄₀H₆₀O₉ 
• 885453-85-0 (25R)-5α-spirostan-2α-O-benzyloxy-3β-ol 
• 885453-83-8 (25R)-5α-spirostan-2α-O-benzyloxy-3α-ol 
• 885453-84-9 C₃₄H₄₈O₄ 

Relevant academic research and scientific papers

Sarsasapogenin-structure-modified derivatives, pharmaceutical compositions thereof and applications of the compositions

The invention relates to sarsasapogenin-structure-modified derivatives. The derivatives are characterized in that the structure formulas of the derivatives are shown as (I) and (II); pharmaceutical compositions of the derivatives and applications thereof are also provided; and many of the newly synthesized compounds show activity superior to activity of lead compounds through activity testing aiming at AD related targets. The compositions have high practical value for treating senile dementia. Defects of sarsasapogenin-structure-modified derivatives in the prior art are made up. The derivatives and the compositions are of great significance.

Synthesis of the cytotoxic gitogenin 3β-O-[2-O-(α-L- rhamnopyranosyl)-β-D-galactopyranoside] and its congeners

(25R)-5a-Spirostan-2a,3b-diol (gitogenin) 3β-O-[2-O-(α-L- rhamnopyranosyl)-β-D-galactopyranoside] (1), a cytotoxic spirostan saponin isolated from the underground parts of Hosta longipes (Liliaceae), was concisely synthesized. In this context, its congeners 2-4 were also prepared. All four compounds showed comparable potency to dioscin in inhibition against the growth of tumor cells. Georg Thieme Verlag Stuttgart.