3964-50-9Relevant academic research and scientific papers
SUPPRESSION OF THE CONVERSION OF 3-t-BUTYL-1-METHYL-1-NITROSOTHIOUREA TO 3-t-BUTYL-1-METHYLUREA BY β-CYCLODEXTRIN UNDER ACIDIC CONDITIONS
Isobe, Masayoshi
, p. 65 - 68 (1985)
The denitrosation of 3-t-butyl-1-methyl-1-nitrosothiourea (1) was retarded by β-, and γ-cyclodextrins (CDs) at pH 4.70.Decomposition of 1 in the presence of β-CD produced selectively 3-t-butyl-1-methylthiourea (1a), which was remarkably different from the product ratio in the absence of β-CD.These results may be caused by both the protective and the microsolvent effect of β-CD.
Electronic and Steric Effects of Alkyl Group on Denitrosation of 3-Alkyl-1-methyl-1-nitrosothioureas
Isobe, Masayoshi
, p. 2844 - 2848 (2007/10/02)
A series of 3-alkyl-1-methyl-1-nitrosothioureas with R=CH3, C2H5, cyclo-C6H11 (3), (CH3)2CH (4), C2H5(CH3)CH, and (CH3)3C were synthesized and their rates of acid catalyzes (pHH:kD is 1.25 for 4.Except 3, a linear plot of log kR/kMe for the denitrosation of RNHCSN(NO)CH3 vs. ?* provides ρ*=-0.98(r=-0.997).The significant factor affecting the rate determining step of the denitrosation of these N-nitrosothioureas at pH 4.6 is the electronic effect of the substituent at the N3 position.
