39640-04-5

Basic information

• Product Name: PIPERAZIN-1-YL-PYRIDIN-4-YL-METHANONE
• Synonyms: PIPERAZIN-1-YL-PYRIDIN-4-YL-METHANONE;1-ISONICOTINOYLPIPERAZINE;Piperazine, 1-(4-pyridinylcarbonyl)- (9CI);1-(PYRIDIN-4-YLCARBONYL)PIPERAZINE;Piperazin-1-yl-pyridin-4-yl-methanone dihydrochloride;1-Piperazinyl(4-pyridinyl)methanone hydrochloride;1-Isonicotinoylpiperazine DiHCl;1-(4-Pyridinecarbonyl)piperazine 2HCl
• CAS NO: 39640-04-5
• Molecular Formula: C₁₀H₁₃N₃O
• Molecular Weight: 191.23
• Product Categories: PIPERIDINE
• Mol File: 39640-04-5.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 369°Cat760mmHg
• Flash Point: 176.9°C
• Appearance: /
• Density: 1.167g/cm³
• Vapor Pressure: 1.23E-05mmHg at 25°C
• CAS DataBase Reference: PIPERAZIN-1-YL-PYRIDIN-4-YL-METHANONE(CAS DataBase Reference)
• NIST Chemistry Reference: PIPERAZIN-1-YL-PYRIDIN-4-YL-METHANONE(39640-04-5)
• EPA Substance Registry System: PIPERAZIN-1-YL-PYRIDIN-4-YL-METHANONE(39640-04-5)

Safety Data

• Hazard Codes: Xn
• Statements: 22
• HazardClass: IRRITANT
• Hazardous Substances Data: 39640-04-5(Hazardous Substances Data)

Usage

General Description

PIPERAZIN-1-YL-PYRIDIN-4-YL-METHANONE is a chemical compound that consists of a piperazine ring and a pyridine ring attached to a methanone group. PIPERAZIN-1-YL-PYRIDIN-4-YL-METHANONE is used in medicinal chemistry for the development of pharmaceutical drugs, particularly as a potential candidate for the treatment of various medical conditions. It has shown promising results in preclinical studies for its potential as a central nervous system (CNS) drug, with potential applications in treating neurological disorders or psychiatric conditions. Additionally, its unique chemical structure makes it a valuable building block for the synthesis of new chemical entities for drug discovery and development. Further research and development may reveal additional potential applications for PIPERAZIN-1-YL-PYRIDIN-4-YL-METHANONE in the pharmaceutical industry.

InChI:InChI=1/C10H13N3O/c14-10(9-1-3-11-4-2-9)13-7-5-12-6-8-13/h1-4,12H,5-8H2/p+1

Upstream product

• 14254-57-0 4-(chlorocarbonyl)pyridine 
• 55-22-1 pyridine-4-carboxylic acid 
• 57260-71-6 1-t-Butoxycarbonylpiperazine 
• 26074-92-0 isonicotinic acid N-hydroxysuccinimidyl ester 
• 163838-89-9 tert-butyl 4-(pyridin-4-ylcarbonyl)piperazine-1-carboxylate 

Relevant articles and documents

Discovery of Novel Apigenin-Piperazine Hybrids as Potent and Selective Poly (ADP-Ribose) Polymerase-1 (PARP-1) Inhibitors for the Treatment of Cancer

Poly (ADP-ribose) polymerase-1 (PARP-1) is a potential target for the discovery of chemosensitizers and anticancer drugs. Amentoflavone (AMF) is reported to be a selective PARP-1 inhibitor. Here, structural modifications and trimming of AMF have led to a series of AMF derivatives (9a-h) and apigenin-piperazine/piperidine hybrids (14a-p, 15a-p, 17a-h, and 19a-f), respectively. Among these compounds, 15l exhibited a potent PARP-1 inhibitory effect (IC50 = 14.7 nM) and possessed high selectivity to PARP-1 over PARP-2 (61.2-fold). Molecular dynamics simulation and the cellular thermal shift assay revealed that 15l directly bound to the PARP-1 structure. In in vitro and in vivo studies, 15l showed a potent chemotherapy sensitizing effect against A549 cells and a selective cytotoxic effect toward SK-OV-3 cells through PARP-1 inhibition. 15l·2HCl also displayed good ADME characteristics, pharmacokinetic parameters, and a desirable safety margin. These findings demonstrated that 15l·2HCl may serve as a lead compound for chemosensitizers and the (BRCA-1)-deficient cancer therapy.

Design, synthesis and evaluation of new classes of nonquaternary reactivators for acetylcholinesterase inhibited by organophosphates

A new series of nonquaternary conjugates for reactivation of both nerve agents and pesticides inhibited hAChE were described in this paper. It was found that substituted salicylaldehydes conjugated to aminobenzamide through piperidine would produce efficient reactivators for sarin, VX and tabun inhibited hAChE, such as L6M1R3, L6M1R5 to L6M1R7, L4M1R3 and L4M1R5 to L4M1R7. The in vitro reactivation experiment for pesticides inhibited hAChE of these new synthesized oximes were conducted for the first time. Despite they were less efficient than obidoxime, some of them were highlighted as equal or more efficient reactivators in comparison to 2-PAM. It was found that introduction of peripheral site ligands could increase oximes’ binding affinity for inhibited hAChE in most cases, which resulted in greater reactivation ability.

2-,3-,4-,5-,6-,7-,8-,9- and/or 10-substituted dibenzoxazepine and dibenzthiazepine compounds, pharmaceutical compositions and methods of use

The present invention provides substituted dibenzoxazepine and dibenzthiazepine compounds of Formula I: STR1 which are useful as analgesic agents for the treatment of pain, and for prostaglandin-E2 mediated diseases, pharmaceutical compositions comprising a therapeutically-effective amount of a compound of Formula I in combination with a pharmaceutically-acceptable carrier, a method for eliminating or ameliorating pain in an animal comprising administering a therapeutically-effective amount of a compound of Formula I to the animal, and a method for treating prostaglandin-E2 mediated diseases in an animal comprising administering a therapeutically-effective amount of a compound of Formula I to the animal.