39640-74-9

Upstream product

• 108-91-8 cyclohexylamine 
• 37167-62-7 bromo-phenyl-acetic acid methyl ester 
• 78907-07-0 methyl 2-(cyclohexylamino)-2-phenylacetate 

Downstream Products

• 31419-13-3 [(1H-benzoimidazol-2-yl)-phenyl-methyl]-cyclohexyl-amine 
• 897446-44-5 N-(2-aminophenyl)-2-(cyclohexylamino)-2-phenylacetamide 

Relevant academic research and scientific papers

Synthesis and biological evaluation of benzimidazole derivatives as potent AMP-activated protein kinase activators

Design, synthesis and structure-activity relationships of benzimidazole derivatives as activators of the AMP-activated protein kinase (AMPK) are presented in this paper. AMPK is the central component of a protein kinase cascade that plays a key role in the regulation of energy balance. Once activated, AMPK initiates a series of responses that are aimed at restoring the energy balance of the cell and recent studies have indicated that AMPK plays an important role in regulation of the whole-body energy metabolism. The following study based on the lead compound S27847 involved modification of three regions of this compound. Preliminary structure-activity relationships are being described.