3967-08-6Relevant academic research and scientific papers
NOVEL 3-SUBSTITUTED-1,4-BENZODIAZEPINES
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Page 31-32, (2010/02/09)
The present invention relates to compounds of formula (I). The invention also relates to methods for preparing the compounds and their uses as CCK receptor ligands and CCK antagonists.
Synthesis of 3-Substituted-amino/aroyloxy-7-chloro-5-phenyl-1,3-dihydro-2H-1,4-benzodiazepin-2-ones as Possible Anxiolytics
Kulkarni, Y. D.,Abdi, s. H. R.,Sharma, V. L.,Dua, P. R.,Shanker, G.
, p. 425 - 426 (2007/10/02)
Ten new 3-substituted-amino/aroyloxy-7-chloro-5-phenyl-1,3-dihydro-2H-1,4-benzodiazepin-2-ones were synthesised and tested for their acute toxicity, effect on gross behaviour and anxiolytic activity using antihypoxia and antimetrazole tests in mice.At 1/5th ALD50, two compounds, one with a morpholino group and the other with a 4-methoxybenzoyloxy group at 3-position exhibited maximum antimetrazole activity similar to oxazepam and also produced significant increase of survival time in antihypoxia test which was comparable to oxazepam.
