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L-Histidine, N-[N-[(phenylmethoxy)carbonyl]-L-a-glutamyl]-, 5-(1,1-dimethylethyl) 1-methyl ester, also known as Fmoc-His(Trt)-OH, is a chemical compound derived from the amino acid L-histidine. It features a protecting group (Fmoc) on the amino group and a trityl (Trt) protecting group on the side chain, along with a tert-butyl (tBu) protecting group on the carboxylic acid group. L-Histidine, N-[N-[(phenylmethoxy)carbonyl]-L-a-glutamyl]-,
5-(1,1-dimethylethyl) 1-methyl ester is integral in the synthesis of peptides and proteins, serving as a building block for the controlled incorporation of L-histidine residues into growing peptide chains. Its stability and versatility make it a valuable component in the creation of specific sequences and structures for research and medical applications.

3967-22-4

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3967-22-4 Usage

Uses

Used in Pharmaceutical Industry:
Fmoc-His(Trt)-OH is utilized as a key component in the synthesis of bioactive peptides and proteins for various pharmaceutical applications. Its role in solid-phase peptide synthesis allows for the precise addition of L-histidine, which is crucial for the development of drugs with specific therapeutic properties.
Used in Research Applications:
In research settings, Fmoc-His(Trt)-OH is employed as a building block for the creation of custom peptides and proteins. Its use enables scientists to explore the functions and interactions of these molecules, contributing to a deeper understanding of biological processes and the development of new therapeutic strategies.
Used in Diagnostic Applications:
Fmoc-His(Trt)-OH contributes to the development of diagnostic tools by allowing for the synthesis of specific peptides and proteins that can be used as markers or probes in various assays and tests, aiding in the detection and monitoring of diseases.
Used in Agricultural Applications:
In agriculture, Fmoc-His(Trt)-OH may be used in the development of biopesticides or other bioactive compounds that can help control pests and diseases, contributing to more sustainable and environmentally friendly farming practices.
Used in Cosmetics Industry:
Fmoc-His(Trt)-OH can be employed in the synthesis of peptides for use in cosmetic products, where they may have anti-aging, skin-repairing, or other beneficial effects, leveraging the specific properties of L-histidine-containing peptides.

Check Digit Verification of cas no

The CAS Registry Mumber 3967-22-4 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 3,9,6 and 7 respectively; the second part has 2 digits, 2 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 3967-22:
(6*3)+(5*9)+(4*6)+(3*7)+(2*2)+(1*2)=114
114 % 10 = 4
So 3967-22-4 is a valid CAS Registry Number.

3967-22-4SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 16, 2017

Revision Date: Aug 16, 2017

1.Identification

1.1 GHS Product identifier

Product name Nα-benzyloxycarbonyl(γ-tert-butyl)glutamylhistidine methyl ester

1.2 Other means of identification

Product number -
Other names Nα-(N-benzyloxycarbonyl-O5-tert-butyl-α-glutamyl)-histidine methyl ester

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:3967-22-4 SDS

3967-22-4Relevant academic research and scientific papers

SYNTHESIS OF A HEPTAPEPTIDE FORMING A MODIFIED ACTH 4-10 FRAGMENT

Krysin, E. P.,Karel'skii, V. N.,Rabinovich, A. K.,Borovkova, S. Yu.

, p. 706 - 709 (2007/10/02)

A scheme is given for the synthesis of a heptapeptide representing a modified ACTH 4-10 fragment on the basis of which it is possible to create a preparation that is an effective adaptogen of peptide nature.A proposed variant of the synthesis permits a peptide with an adequate degree of purity to be obtained comparatively simply on a large scale.The intermediate compunds and the final products were obtained with good yields and were distinguished by chromatographic homogeneity.The heptapeptide synthesized did not differ with respect to its physicochemical characteristics and biological action from the analogous compound obtained previously.Some physicochemical characteristics of the compound obtained (angles of optical rotation, chromatographic mobilities) are given.

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